Genetics: Analysis and Principles
5th Edition
ISBN: 9780073525341
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 24, Problem 23CONQ
Summary Introduction
To review:
The retroviral oncogene and its use in viral proliferation and infection. Also, review the process of acquiring oncogenes by a retrovirus.
Introduction:
The oncogenes are the genes which help in the formation of cancer cells. When different mutations occur in proto-oncogenes, they are converted into oncogenes. There are many agents which cause cancer that can be internal or external. Viruses are also significant agents which can cause cancer in the body and spreads throughout the body if not treated.
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19. On the diagram below
a. Label the three pictures as: DNA; polypeptide; or RNA.
b. Label the arrows as: translation or transcription/RNA processing.
c. Add the following details to the diagram.
Promoter region
TATA box
Transcription start site
Transcription terminator
Intron (A,B,C,D)
Exons (1,2,3,4,5)
Splice sites
5' cap
5' UTR (untranslated region)
3' poly A tail
3' UTR (untranslated region)
Translational start (AUG)
Translational stop (UGA, UAG, or UAA)
N and C ends of polypeptide
0000
Match the letter labels in the figure below to the terms. Some letter
labels are not used.
MNNNNNNIN
M
C
B
A
M
D
F
E
H
K
G
8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
Chapter 24 Solutions
Genetics: Analysis and Principles
Ch. 24.1 - Which of the following wouldnotbe consistent with...Ch. 24.1 - 2. Assuming complete penetrance, which type of...Ch. 24.1 - 3. Which of the following is not a common...Ch. 24.1 - Prob. 4COMQCh. 24.2 - Prob. 1COMQCh. 24.2 - Haplotype association studies are aimed at the...Ch. 24.3 - 1. Which of the following is not a method used in...Ch. 24.3 - 2. Which of the following prenatal genetic testing...Ch. 24.4 - Prob. 1COMQCh. 24.5 - 1. An oncogene is produced from a ________that has...
Ch. 24.5 - Which of the following is a type of genetic change...Ch. 24.5 - 3. Tumor-suppressor genes promote cancer...Ch. 24.5 - 4. Normal (nonmutant) tumor-suppressor genes often...Ch. 24.5 - Prob. 5COMQCh. 24.6 - Prob. 1COMQCh. 24 - 1. With regard to pedigree analysis, make a list...Ch. 24 - 2. Explain, at the molecular level, why human...Ch. 24 - 3. Many genetic disorders exhibit locus...Ch. 24 - Prob. 4CONQCh. 24 - Prob. 5CONQCh. 24 - Figure 25.1 illustrates albinism in two different...Ch. 24 - Prob. 7CONQCh. 24 - Prob. 8CONQCh. 24 - Ehler-Danlos syndrome is a rare disorder caused by...Ch. 24 - 10. Hurler syndrome is due to a mutation in a gene...Ch. 24 - Like Hurler syndrome, Fabry disease involves an...Ch. 24 - Achondroplasia is a rare form of dwarfism caused...Ch. 24 - Prob. 13CONQCh. 24 - 14. Marfan syndrome is due to a mutation in a...Ch. 24 - 15. Sandhoff disease is due to a mutation in a...Ch. 24 - Describe the two assumptions that underlie the...Ch. 24 - Prob. 17CONQCh. 24 - What is a prion? Explain how a prion relies on...Ch. 24 - 19. Some people have a genetic predisposition for...Ch. 24 - What is the difference between an oncogene and a...Ch. 24 - C20. Familial fatal insomnia (described in Table)...Ch. 24 - Prob. 22CONQCh. 24 - Prob. 23CONQCh. 24 - Prob. 24CONQCh. 24 - Prob. 25CONQCh. 24 - Prob. 26CONQCh. 24 - Prob. 27CONQCh. 24 - Prob. 28CONQCh. 24 - With regard to cancer cells, which of the...Ch. 24 - Prob. 30CONQCh. 24 - 1. Which of the following experimental...Ch. 24 - Prob. 2EQCh. 24 - 3. What is meant by the term genetic testing? How...Ch. 24 - Prob. 4EQCh. 24 - 5. Chapter 21 describes a method known as Western...Ch. 24 - 6. An experimental assay for the blood-clotting...Ch. 24 - 7. Discuss ways to distinguish whether a...Ch. 24 - 8. The codon change (Gly-12 to Val-12) in...Ch. 24 - Explain how DNA microarrays are used in molecular...Ch. 24 - E7. Lets suppose a cell line has become malignant...Ch. 24 - Prob. 8EQCh. 24 - Prob. 9EQCh. 24 - Prob. 10EQCh. 24 - Prob. 13EQCh. 24 - Make a list of the benefits that may arise from...Ch. 24 - Our government has finite funds to devote to...
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