FUNDAMENTALS OF BIOCHEMISTRY - LL FD
FUNDAMENTALS OF BIOCHEMISTRY - LL FD
5th Edition
ISBN: 9781119598022
Author: Voet
Publisher: WILEY
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Chapter 24, Problem 22E
Summary Introduction

To draw: The structure of ornithine decarboxylase reaction product.

Concept introduction: Decarboxylation of ornithine is the irreversible step catalyzed by the enzyme ornithine decarboxylase for polyamine synthesis. Ornithine is a product of urea cycle that is converted to putrescine by the action of ornithine decarboxylase. This enzyme is essential for stabilization of the newly produced DNA through the synthesis of polyamine molecules. The absence of this enzyme causes DNA damage and apoptosis in cells.

Summary Introduction

To explain: How ornithine decarboxylase reaction product (putrescine) interacts with the DNA.

Concept introduction: Decarboxylation of ornithine is the irreversible step catalyzed by the enzyme ornithine decarboxylase for polyamine synthesis. Ornithine is a product of urea cycle that is converted to putrescine by the action of ornithine decarboxylase. This enzyme is essential for stabilization of the newly produced DNA through the synthesis of polyamine molecules. The absence of this enzyme causes DNA damage and apoptosis in cells.

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