What is Life? A Guide to Biology with Physiology
What is Life? A Guide to Biology with Physiology
3rd Edition
ISBN: 9781464157745
Author: Jay Phelan
Publisher: W. H. Freeman
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Chapter 24, Problem 11SA
Summary Introduction

To review:

  1. The general effects of endocrine disrupters.
  2. Why even small quantities of these substances can be dangerous.

Introduction:

Many chemicals are capable of disrupting the function of hormones.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
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