Chapter 23.SE, Problem 34MP

Interpretation Introduction

Interpretation:

A mechanism for the reaction shown, a step involved in the metabolization of leucine, is to be proposed.

Concept introduction:

The reaction shown is a reverse aldol reaction. It takes place in three steps i) Deprotonation by the base ii) Elimination of acetylCoA enolate iii) Protonation of the enolate to yield acetylCoA.

To propose:

A mechanism for the reaction shown, a step involved in the metabolization of leucine.