For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide Concept Introduction : An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products. Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines. Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines. Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Question

Want to see the full answer?

Answer 1

Question

Chapter 23.7, Problem 20PTS

(a)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(b)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(c)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(d)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(e)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(f)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

(EXM 2, PRBLM 3) Here is this problem, can you explain it to me and show how its done. Thank you I need to see the work for like prbl solving.

can someone draw out the reaction mechanism for this reaction showing all bonds, intermediates and side products Comment on the general features of the 1H-NMR spectrum of isoamyl ester provided below

What would be the best choices for the missing reagents 1 and 3 in this synthesis? 1. PPh3 3 2. n-BuLi • Draw the missing reagents in the drawing area below. You can draw them in any arrangement you like. • Do not draw the missing reagent 2. If you draw 1 correctly, we'll know what it is. • Note: if one of your reagents needs to contain a halogen, use bromine. Click and drag to start drawing a structure.

Answer 2

Question

Chapter 23.7, Problem 20PTS

(a)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(b)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(c)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(d)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(e)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(f)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 23.7, Problem 20PTS

(a)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(b)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(c)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(d)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(e)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(f)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 23.7, Problem 20PTS

(a)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(b)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(c)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(d)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(e)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(f)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 5

Chapter 23.7, Problem 20PTS

(a)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(b)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(c)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(d)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(e)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

(f)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 6

Chapter 23.7, Problem 20PTS

(a)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 7

Chapter 23.7, Problem 20PTS

(a)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 8

(b)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 9

(b)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 10

(c)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 11

(c)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 12

(d)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 13

(d)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 14

(e)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 15

(e)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 16

(f)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 17

(f)

Interpretation Introduction

Interpretation: For a given compound set of compounds, the given amines are to be prepared via an azide synthesis, reductive amination starting from sodium azide

Concept Introduction: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary amines are synthesized while secondary and tertiary amines are not formed as by-products.

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

Answer 18

Expert Solution & Answer

Answer 19

Expert Solution & Answer

Answer 20

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 21

Ch. 23.2 - Prob. 1LTS Ch. 23.2 - Prob. 1PTS Ch. 23.2 - Prob. 2ATS Ch. 23.2 - Prob. 3ATS Ch. 23.3 - Prob. 4CC Ch. 23.3 - Prob. 5CC Ch. 23.3 - Prob. 6CC Ch. 23.3 - Prob. 7CC Ch. 23.3 - Prob. 8CC Ch. 23.3 - Prob. 9CC

Want to see the full answer?

Chapter 23 Solutions