EP MICROBIOLOGY:W/DISEASES BY..-MOD.ACC
5th Edition
ISBN: 9780134607894
Author: BAUMAN
Publisher: PEARSON CO
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Chapter 23, Problem 7CT
Summary Introduction
To answer:
Whythere is no vaccine for the hepatitis delta virus, and why researchers are not seeking to develop a vaccineagainst delta virus and its marketing status.
Introduction:
Hepatitis D virus is an RNA virus that requires hepatitis B virus for replication. This virus is transmitted by the infected person through contact with the blood.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 23 Solutions
EP MICROBIOLOGY:W/DISEASES BY..-MOD.ACC
Ch. 23 - Prob. 1TMWCh. 23 - Prob. 2TMWCh. 23 - Why is the elimination of sucrose sugar from the...Ch. 23 - Prob. 1CCSCh. 23 - The Case of the Lactovegetarians Two patientsa...Ch. 23 - Prob. 4TMWCh. 23 - Prob. 1EDCSCh. 23 - Why does the visually distinctive appearance of...Ch. 23 - Prob. 3CCSCh. 23 - Prob. 6TMW
Ch. 23 - Which of the following is not part of the...Ch. 23 - Prob. 2MCCh. 23 - Prob. 3MCCh. 23 - Prob. 4MCCh. 23 - Which of the following is a virulence factor...Ch. 23 - Prob. 6MCCh. 23 - Prob. 7MCCh. 23 - Prob. 8MCCh. 23 - Prob. 9MCCh. 23 - One of the more common waterborne gastrointestinal...Ch. 23 - Prob. 11MCCh. 23 - Prob. 12MCCh. 23 - Prob. 13MCCh. 23 - Prob. 14MCCh. 23 - Prob. 15MCCh. 23 - Prob. 1MTFCh. 23 - Prob. 2MTFCh. 23 - Prob. 3MTFCh. 23 - Prob. 4MTFCh. 23 - Prob. 5MTFCh. 23 - Prob. 6MTFCh. 23 - Prob. 7MTFCh. 23 - Prob. 8MTFCh. 23 - Prob. 9MTFCh. 23 - Prob. 10MTFCh. 23 - Prob. 1FIBCh. 23 - Prob. 2FIBCh. 23 - Fill in the Blanks 3. Peptic ulcers collectively...Ch. 23 - Prob. 4FIBCh. 23 - Prob. 5FIBCh. 23 - Fill in the Blanks 6. Swelling of the parotid...Ch. 23 - Prob. 7FIBCh. 23 - Fill in the Blanks 8. Discovering oval cysts that...Ch. 23 - Prob. 9FIBCh. 23 - Prob. 10FIBCh. 23 - Prob. 1MCh. 23 - What role does the normal microbiome play in...Ch. 23 - Prob. 2SACh. 23 - Prob. 3SACh. 23 - Prob. 4SACh. 23 - Prob. 5SACh. 23 - Prob. 6SACh. 23 - Prob. 7SACh. 23 - Prob. 8SACh. 23 - Prob. 9SACh. 23 - Prob. 10SACh. 23 - Prob. 1VICh. 23 - Prob. 2VICh. 23 - Prob. 1CTCh. 23 - Prob. 2CTCh. 23 - Prob. 3CTCh. 23 - Infections with HBV and HCV usually take years....Ch. 23 - Why did soldiers living in battlefield trenches in...Ch. 23 - Prob. 6CTCh. 23 - Prob. 7CTCh. 23 - Prob. 8CTCh. 23 - Prob. 9CTCh. 23 - Prob. 10CTCh. 23 - Prob. 11CTCh. 23 - Prob. 12CTCh. 23 - Why and when should parents have their children...Ch. 23 - Prob. 14CTCh. 23 - Using the following terms, complete this concept...
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