Biochemistry
8th Edition
ISBN: 9781285429106
Author: Campbell, Mary K., FARRELL, Shawn O.
Publisher: Cengage Learning,
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Chapter 23, Problem 45RE
RECALL How many high-energy phosphate bonds must be hydrolyzed in the pathway that produces GMP from guanine and PRPP by the PRPP salvage reaction, compared with the number of such bonds hydrolyzed in the pathway leading to IMP and then to GMP?
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Extracts from the bacterium Bacillus brevis contain a peptide with antibiotic properties. This peptide forms complexes with
metal ions and seems to disrupt ion transport across the cell membranes of other bacterial species, leading to bacterial death.
The structure of the peptide has been determined from a series of observations.
(a) Complete acid hydrolysis of the peptide, followed by amino acid analysis, yielded equimolar amounts of Leu, Orn, Phe, Pro,
and Val. Orn is ornithine, an amino acid not present in proteins but present in some peptides. Orn has the structure
H
'H,N-CH,
-
CH2 CH2 CH2 -
C - COO-
NH,
(b) The molecular weight of the peptide is approximately 1,200 Da.
(c) The peptide failed to undergo hydrolysis when treated with the enzyme carboxypeptidase. This enzyme catalyzes the
hydrolysis of the carboxyl-terminal residue of a polypeptide unless the residue is Pro or the peptide does not contain a free
carboxyl group.
(d) Treatment of the intact peptide with…
At a pH equal to the isoelectric point (pl) of alanine, the net charge of alanine is zero. Two structures can be drawn that have a
net charge of zero, but the predominant form of alanine at its pl is zwitterionic.
CH3
H,N
CH3
**
H¸N-C
H
Zwitterionic
H
Uncharged
OH
Select statements that explain why alanine is predominantly zwitterionic at its pl.
pk of alanine's amino group is more than its pl.
pk of alanine's carboxyl group is more than its pl.
PK of alanine's carboxyl group is less than its pl.
pk of alanine's amino group is less than its pl.
Correct Answer
What fraction of alanine is in the completely uncharged form at its pl?
1 in 2.2 × 107
1 in 1.6 × 10²
1 in 4680
1 in 9460
How does a voltage-gated sodium channel work? Specifically, how and why does a change in voltage trigger their opening? Please be detailed
Chapter 23 Solutions
Biochemistry
Ch. 23 - RECALL What kinds of organisms can fix nitrogen?...Ch. 23 - RECALL How is nitrogen fixed (converted from...Ch. 23 - Prob. 3RECh. 23 - Prob. 4RECh. 23 - Prob. 5RECh. 23 - Prob. 6RECh. 23 - Prob. 7RECh. 23 - REFLECT AND APPLY Metabolic cycles are rather...Ch. 23 - RECALL What is the relationship between...Ch. 23 - Prob. 10RE
Ch. 23 - Prob. 11RECh. 23 - Prob. 12RECh. 23 - Prob. 13RECh. 23 - Prob. 14RECh. 23 - Prob. 15RECh. 23 - Prob. 16RECh. 23 - Prob. 17RECh. 23 - Prob. 18RECh. 23 - REFLECT AND APPLY Sulfanilamide and related sulfa...Ch. 23 - Prob. 20RECh. 23 - Prob. 21RECh. 23 - Prob. 22RECh. 23 - Prob. 23RECh. 23 - Prob. 24RECh. 23 - RECALL Describe citrulline and ornithine based on...Ch. 23 - Prob. 26RECh. 23 - Prob. 27RECh. 23 - Prob. 28RECh. 23 - Prob. 29RECh. 23 - Prob. 30RECh. 23 - Prob. 31RECh. 23 - Prob. 32RECh. 23 - Prob. 33RECh. 23 - Prob. 34RECh. 23 - Prob. 35RECh. 23 - Prob. 36RECh. 23 - REFLECT AND APPLY Why is it better, when running a...Ch. 23 - REFLECT AND APPLY Argue logically that the urea...Ch. 23 - BIOCHEMICAL CONNECTIONS How is the importance of...Ch. 23 - Prob. 40RECh. 23 - RECALL What is the structural difference between...Ch. 23 - Prob. 42RECh. 23 - RECALL Does the conversion of IMP to GMP use or...Ch. 23 - RECALL Discuss the role of feedback inhibition in...Ch. 23 - RECALL How many high-energy phosphate bonds must...Ch. 23 - REFLECT AND APPLY Why do most mammals, other than...Ch. 23 - Prob. 47RECh. 23 - RECALL Compare the fates of the products of purine...Ch. 23 - Prob. 49RECh. 23 - Prob. 50RECh. 23 - REFLECT AND APPLY Chemotherapy patients receiving...
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