The consequences of a carnitine deficiency for fatty acid oxidation should be discussed. Concept Introduction: Most of the enzymes of ß oxidation pathway are in the mitochondrial matrix. Short chain fatty acids are transported to the matrix as free acids and convert to acyl CoA derivatives. Long chain fatty acids cannot be transported to the matrix directly. Therefore, they must be converted to acylcarnitine derivatives. Carnitine acyltransferase I is associated with the outer mitochondrial membrane. It catalyzes the formation of O-acylcarnitine. This is transported across the inner mitochondrial membrane by translocase. Then acylcarnitine is transferred to carnitine acyltransferase II on matrix side. This enzyme transfers fatty acyl group back to CoA leaving free carnitine which can return across the membrane via translocase.

Question

Want to see the full answer?

Answer 1

Question

Chapter 23, Problem 10P

Interpretation Introduction

Interpretation:

The consequences of a carnitine deficiency for fatty acid oxidation should be discussed.

Concept Introduction:

Most of the enzymes of ß oxidation pathway are in the mitochondrial matrix. Short chain fatty acids are transported to the matrix as free acids and convert to acyl CoA derivatives. Long chain fatty acids cannot be transported to the matrix directly. Therefore, they must be converted to acylcarnitine derivatives. Carnitine acyltransferase I is associated with the outer mitochondrial membrane. It catalyzes the formation of O-acylcarnitine. This is transported across the inner mitochondrial membrane by translocase. Then acylcarnitine is transferred to carnitine acyltransferase II on matrix side. This enzyme transfers fatty acyl group back to CoA leaving free carnitine which can return across the membrane via translocase.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

9) Below, there is a representation of an SDS-PAGE gel. Assuming the samples in the MW standard have masses of: 66 kDa, 45 kDa, 36 kDa, 29 kDa, 24 kDa, 20.1 kDa, and 14.2 kDa, a) Figure 4: indicate where each of the measurements were taken and label as in II.6. figure 2 above. b) As in II.7. Table 1 above create Table 2 using the data below. Determine the r.f. values for the MW standards, plot the relative mobility versus the log of the mass for the standards, and use the best fit straight line to determine the molecular weights of the proteins in the whey, peak 1, and peak 2 lanes. (5 pts—this will be scaled up appropriately if your gel did not develop properly) dye MW Whey Peak 1 Peak 2

what are the different classes and some examples of neuroprotectants that can be used to treat, prevent, or combat neurotoxicity/a neurotoxicant...for example, antioxidants, nutraceuticals, etc.,..?

Imagine that aldolase can react with the seven carbon molecule Sedoheptulose-1,7-bisphosphate (below). Use the mechanism to predict the two products generated. Please draw out the stereochemistry in a fischer projection.