Chapter 22.7, Problem 16P

Interpretation Introduction

a)

Interpretation:

Using an alkylation reaction as the key step how the compound shown can be prepared is to be given.

Concept introduction:

An alkylation reaction is used to introduce a methyl or a primary alkyl group in α- position of a ketone, ester or nitrile by a ^SN² reaction of the enolate ion with an alkyl halide. Thus by looking at α- carbon of the product, the alkyl halide to be used in the reaction can be identified. The enolate ion can be produced by using lithium diisopropylamide (LDA).

To give:

Using an alkylation reaction as the key step how to prepare the compound shown.

Interpretation Introduction

b)

Interpretation:

Using an alkylation reaction as the key step how the compound shown can be prepared.

Concept introduction:

An alkylation reaction is used to introduce a methyl or a primary alkyl group in α- position of a ketone, ester or nitrile by a ^SN² reaction of the enolate ion with an alkyl halide. Thus by looking at α- carbon of the product the alkyl halide to be used in the reaction can be identified. The enolate ion can be produced by using lithium diisopropylamide (LDA).

To give:

Using an alkylation reaction as the key step how to prepare the compound shown.

Interpretation Introduction

c)

Interpretation:

Using an alkylation reaction as the key step how the compound shown can be prepared.

Concept introduction:

An alkylation reaction is used to introduce a methyl or a primary alkyl group in α- position of a ketone, ester or nitrile by a^SN²reaction of the enolate ion with an alkyl halide. Thus by looking at α- carbon of the product the alkyl halide to be used in the reaction can be identified. The enolate ion can be produced by using lithium diisopropylamide (LDA).

To give:

Using an alkylation reaction as the key step how to prepare the compound shown.

Interpretation Introduction

d)

Interpretation:

Using an alkylation reaction as the key step how the compound shown can be prepared.

Concept introduction:

An alkylation reaction is used to introduce a methyl or a primary alkyl group in α- position of a ketone, ester or nitrile by a ^SN² reaction of the enolate ion with an alkyl halide. Thus by looking at α- carbon of the product the alkyl halide to be used in the reaction can be identified. The enolate ion can be produced by using lithium diisopropylamide (LDA).

To give:

Using an alkylation reaction as the key step how to prepare the compound shown.

Interpretation Introduction

e)

Interpretation:

Using an alkylation reaction as the key step how the compound shown can be prepared.

Concept introduction:

An alkylation reaction is used to introduce a methyl or a primary alkyl group in α- position of a ketone, ester or nitrile by a ^SN² reaction of the enolate ion with an alkyl halide. Thus by looking at α- carbon of the product the alkyl halide to be used in the reaction can be identified. The enolate ion can be produced by using lithium diisopropylamide (LDA).

To give:

Using an alkylation reaction as the key step how to prepare the compound shown.

Interpretation Introduction

f)

Interpretation:

Using an alkylation reaction as the key step how the compound shown can be prepared.

Concept introduction:

An alkylation reaction is used to introduce a methyl or a primary alkyl group in α- position of a ketone, ester or nitrile by a ^SN² reaction of the enolate ion with an alkyl halide. Thus by looking at α- carbon of the product the alkyl halide to be used in the reaction can be identified. The enolate ion can be produced by using lithium diisopropylamide (LDA).

To give:

Using an alkylation reaction as the key step how to prepare the compound shown.