Chapter 22, Problem 52PP

Interpretation Introduction

Interpretation: The major product of methadone has to be found via Hofmann elimination

Concept Introduction:

The reagents such as methyl iodide and silver oxide are given and used as the reaction conditions in the given reactions.  This reaction is called Hofmann elimination.  The amines undergo exhaustive alkylation in the presence of excess methyl iodide producing quaternary ammonium salt which is a excellent leaving group.  After treatment with strong base, aqueous silver oxide and heat, quaternary ammonium salt gives alkenes.  Alkene formation involves in E2 elimination.  Through E2 elimination, the major product is less substituted alkene with trace amount of more substituted alkene.

To find: The major product of methadone via Hofmann elimination

Draw and analyze the structure of methadone