Human Biology (MindTap Course List)
11th Edition
ISBN: 9781305112100
Author: Cecie Starr, Beverly McMillan
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Question
Chapter 22, Problem 3RQ
Summary Introduction
To summarize: The roles of proto-oncogenes, oncogenes, and tumor suppressor genes in carcinogenesis.
Introduction: Cancer is caused due to abnormal cell growth. This occurs due to several genetic and epigenetic alterations that cause uncontrolled proliferation of cells. The clinical manifestations of cancer are numerous and depend on the variety and intensity of symptoms.
The word tumor is used to refer swelling, but now it is used to describe the new growth or neoplasm (cancerous growth).
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Although cancer is not a contagious disease in humans or other vertebrates, there have been rare cases in which cancers have spread from one organism to another. Describe three cases of these contagious cancers and what conditions might have led to their appearance. For an introduction to this topic, see http:// www.cancer.org/cancer/cancerbasics/is-cancer-contagious.
The Human papillomavirus (HPV) has been linked to an increased risk of cervical cancer. The HPV E6 and E7 proteins govern the cell via altering cellular proteins. The E6 protein interacts with the tumor suppressor protein p53 and directs its ubiquitin-mediated destruction.
Can you elaborate about the P63 gene: its function and if it can be altered/mutated by HPV? If it does, what is the relationship between P53 and P63?
Thank you!
I’m having trouble with this fill in the blank. Could you please let me know if I need to change any of my answers.
Chapter 22 Solutions
Human Biology (MindTap Course List)
Ch. 22 - Prob. 1RQCh. 22 - Prob. 2RQCh. 22 - Prob. 3RQCh. 22 - Prob. 4RQCh. 22 - Prob. 5RQCh. 22 - Prob. 6RQCh. 22 - Prob. 1SQCh. 22 - Prob. 2SQCh. 22 - Prob. 3SQCh. 22 - Prob. 4SQ
Ch. 22 - Prob. 5SQCh. 22 - Tumor suppressor genes _____. a. occur normally in...Ch. 22 - Prob. 7SQCh. 22 - The most common therapeutic approaches to treating...Ch. 22 - Prob. 9SQCh. 22 - Prob. 10SQCh. 22 - Prob. 1CTCh. 22 - A textbook on cancer contains the following...Ch. 22 - Ultimately, cancer kills because it spreads and...Ch. 22 - Over the last few months, your best friend, Mark,...Ch. 22 - Some desperate cancer patients consume pills or...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Cancer is a genetic disease. To provide evidence that you understand cancer genes are altered in both sporadic (somatic) and inherited cancers, match the beginning and end of the sentences below to give correct statements.arrow_forwardOut of these 8 hallmarks ( sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, deregulating cellular energetics and metabolism, and avoiding immune destruction). Rank them from least important to most for cancer development. Explain in 2-3 sentences how.arrow_forward"In the cellular regulatory pathways that control cell growth and proliferation, the products of oncogenes are stimulatory components and the products of tumor suppressor genes are inhibitory components" is true or false.arrow_forward
- Carcinogens generate mutations in: Question 17 options: anti-oncogenes and tumor activation genes proto-oncogenes and tumor suppressor genes proto-oncogenes and tumor activation genes anti-oncogenes and tumor suppressor genesarrow_forwardThe C-myc gene is a proto-oncogene which is highly expressed in breast tissue and appears to cause proliferation of breast tissue and its elevated expression is associated with breast cancer. Based just on the ChIP data from the previous questions (also shown below), which of the three drugs (estrogen, tamoxifen and raloxifene) would you recommend for treating breast cancer? Justify your response and explain the potential side effects of each drug.arrow_forwardCompare and contrast oncogenes and tumor suppressors. Contrast oncogenes and proto-oncogenes. Describe the types of mutations that convert proto-oncogenes into oncogenes. Summarize some functions of common oncogenes in cell survival and uncontrolled growth. Contrast tumor suppressors to oncogenes. Describe the types of mutations in tumor suppressors that are found in common cancers. Summarize the functions of common tumor suppressors in cell survival and cell growth.arrow_forward
- Relatively few inherited forms of cancer involve the inheritance of mutant oncogenes. Instead, most inherited forms of cancer are defects in tumor-suppressor genes. Give two or more reasons why inherited forms of cancer seldom involve activated oncogenes.arrow_forwardIn 2010, the U.S. Department of Health and Human Services added alcoholic beverages to its list of known human carcinogens. Explain what types of cancer alcohol is related to; what steps should be taken to reduce the risk of developing alcohol-induced cancer; and what other factors, when combined with alcohol, increase the risk of developing cancer.arrow_forwardRead the scenario presented in the picture. The conditions employed in laboratory settings could mimic the outcomes of prolonged usage of tamoxifen and hormone deprivation therapy. We don't know much about the phenotypic profile of these newly emerged cancer cells. How might you explain the lack of response of TamC3 to tamoxifen treatment and TamR3 to estrogen deprivation?arrow_forward
- Despite being small animals, naked mole rats are almost entirely resistant to cancer. Watch the following brief video on one potential mechanism for the prevention of cancer in naked mole rats. https://youtu.be/bhNBeuhxkF0?si=38aelHLW1N6vN8-b Based on what you know about mitosis and cancer cells, why would a mechanism that prevents cell crowding reduce the likelihood of cancer developing?arrow_forwardTissues and differentiation a)Explain what is meant by termination and differentiation ).b) Explain the difference between an oncogenic and a tumour suppressor gene and describe how they are involved in the onset of cancerarrow_forwardAbnormally high levels of prostate specific antigen (PSA) in a patient's blood is used to screen for prostate cancer. PSA is expressed in nomal, non-cancerous prostate cells. a) Why would elevated levels of PSA be suggestive of prostate cancer given what you know about cancer? Answer in no more than two sentences. b) Are high PSA levels sufficient to confim that a patient has prostate cancer, as opposed to a benign tumor? Why or why not? Explain in one sentence only.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Biology (MindTap Course List)BiologyISBN:9781305112100Author:Cecie Starr, Beverly McMillanPublisher:Cengage LearningHuman Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Biology (MindTap Course List)
Biology
ISBN:9781305112100
Author:Cecie Starr, Beverly McMillan
Publisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
What are Mutations and what are the different types of Mutations?; Author: Science ABC;https://www.youtube.com/watch?v=I16YlE8qTBU;License: Standard youtube license