FUNDAMENTALS OF BIOCHEMISTRY WPNG 1-SEME
FUNDAMENTALS OF BIOCHEMISTRY WPNG 1-SEME
5th Edition
ISBN: 9781119750192
Author: Voet
Publisher: WILEY
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Chapter 22, Problem 35CQ
Summary Introduction

To suggest:  A metabolite that is responsible for the protein kinase C activation.

Concept introduction: Protein kinase C (PKC) is a family of protein kinase enzyme that is involved in controlling the function of other proteins by phosphorylation of the hydroxyl groups of serine and threonine amino acid residues on these proteins or a member of this family. 15 isozymes of the PKC family are identified in humans.

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The ∆G°’ for hydrolysis of phosphoenol pyruvate is -62.2 kJ/mol. The standard freeenergy of ATP hydrolysis is -30.5 kJ/mol. A. What is the standard free energy and K eq of the spontaneous reaction betweenADP/ATP and phosphoenol pyruvate. B. Repeat A for F-1,6-BP (∆G°’=-16.7 kJ/mol) and 1,3-BPG (∆G°’=-49.6 kJ/mol)hydrolysis. C. If the ATP and ADP concentrations are 8mM and 1mM respectively, what would bethe ratio of pyruvate/phosphoenolpyruvate at equilibrium?
Answer
13. Which one is the major organic product of the following sequence of reactions? A OH (CH3)2CHCH2COOH SOCI2 CH3OH 1. CH3MgBr 2. H₂O, H+ B C D OH E OH
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