The addition of Grignard reagent to an ester or a nitrile to synthesize 4 -phenylheptan- 4 -ol is to be explained. Concept introduction: The grignard reagent is used to generate R − carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

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Answer 1

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Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 21.9, Problem 21.28P

(a)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize 4-phenylheptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

(b)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize heptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

(c)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize pentan-2-one is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the nitrile group into ketone group.

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achieve.macmillanlearning.com Canvas EA eac h Hulu YouTube G 3 methyl cyclobutanol - Google Search Ranking Phenol Acidity Course -236 - Organic Chemistry - Mac... ← Assessment Completed 10 of 22 Questions 1 + Netflix paramount plus chem hw Galdehyde reaction with grignard reagent... b My Questions | bartleby M Inbox - chenteislegit@gmail.com - Gmail Due: Fri, Jan 31 Resources Solution Penalized ? Hint Submit Answer Use retrosynthetic analysis to suggest two paths to synthesize 2-methyl-3-hexanol using the Grignard reaction. (Click and drag the appropriate image to the correct position in the reactions.) Route 1 Aldehyde 1 or +98 Aldehyde 2 Route 2 Q6 +100 Solved in 1 attempt Q7 +95 Solved in 2 attempts Q8 +98 Unlimited attempts possible + + Grignard 1 OH H3O+ Grignard 2 Answer Bank Q9 +90 MgBr Unlimited attempts possible CH3CH2CH2MgBr Q10 Unlimited attempts Q11 ? ? +100 in 1 attempt 2-methyl-3-hexanol CH3CH2MgBr H H о H Attempt 3

2) (4 pt) After the reaction was completed, the student collected the following data. Crude product data is the data collected after the reaction is finished, but before the product is purified. "Pure" product data is the data collected after attempted purification using recrystallization. Student B's data: Crude product data "Pure" product data after recrystallization Crude mass: 0.93 g grey solid Crude mp: 96-106 °C Crude % yield: Pure mass: 0.39 g white solid Pure mp: 111-113 °C Pure % yield: a) Calculate the crude and pure percent yields for the student's reaction. b) Summarize what is indicated by the crude and pure melting points.

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Answer 2

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Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 21.9, Problem 21.28P

(a)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize 4-phenylheptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

(b)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize heptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

(c)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize pentan-2-one is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the nitrile group into ketone group.

Expert Solution & Answer

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Answer 3

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 21.9, Problem 21.28P

(a)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize 4-phenylheptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

(b)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize heptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

(c)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize pentan-2-one is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the nitrile group into ketone group.

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Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 21.9, Problem 21.28P

(a)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize 4-phenylheptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

(b)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize heptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

(c)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize pentan-2-one is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the nitrile group into ketone group.

Expert Solution & Answer

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Answer 5

Chapter 21.9, Problem 21.28P

(a)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize 4-phenylheptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

(b)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize heptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

(c)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize pentan-2-one is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the nitrile group into ketone group.

Answer 6

Chapter 21.9, Problem 21.28P

(a)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize 4-phenylheptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

Answer 7

Chapter 21.9, Problem 21.28P

(a)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize 4-phenylheptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

Answer 8

(b)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize heptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

Answer 9

(b)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize heptan-4-ol is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks on electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the carbonyl group into alcohol.

Answer 10

(c)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize pentan-2-one is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the nitrile group into ketone group.

Answer 11

(c)

Interpretation Introduction

Interpretation:

The addition of Grignard reagent to an ester or a nitrile to synthesize pentan-2-one is to be explained.

Concept introduction:

The grignard reagent is used to generate R− carbanion which attacks electron deficient center. Carbonyl group that has good leaving group gives substituted products. This reagent is used to convert the nitrile group into ketone group.

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 21.2F - Name the following carboxylic acid derivatives,...Ch. 21.4A - Prob. 21.2P Ch. 21.4A - Prob. 21.3P Ch. 21.4A - Prob. 21.4P Ch. 21.5C - Prob. 21.7P Ch. 21.6 - When ethyl 4-hydroxybutyrate is heated in the...Ch. 21.6 - Propose a mechanism for the following ring-opening...Ch. 21.6 - Prob. 21.15P Ch. 21.7B - Prob. 21.16P Ch. 21.7C - Prob. 21.19P

Solution Summary: The author explains the mechanism of the addition of Grignard reagent to an ester or a nitrile to synthesize heptan- 4 -ol.

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Chapter 21 Solutions