How cellular and molecular events are responsible for emergent properties at individual and population level. Introduction: The events taking place at molecular or cellular level can lead to emergent properties at individual level or population level. The heterozygote alleles are favored rather than homozygotes at cellular level. In humans, this advantage can be seen at a locus coding for ß polypeptide (subunit of hemoglobin).

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Chapter 21, Problem 9TYU

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How cellular and molecular events are responsible for emergent properties at individual and population level.

Introduction:

The events taking place at molecular or cellular level can lead to emergent properties at individual level or population level. The heterozygote alleles are favored rather than homozygotes at cellular level. In humans, this advantage can be seen at a locus coding for ß polypeptide (subunit of hemoglobin).

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Sickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of the genetic defect. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to survive better than either of the homozygous conditions. 11% of an African population is born with a severe form of sickle-cell anemia (ss), What is the frequency of the dominant allele? Please show your work in order to receive credit.

Sickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of this genetic defect causes deformation of red blood cells. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to survive better than either of the homozygous conditions. Assuming HWE, if 9% of an African population is born with a severe form of sickle-cell anemia (ss), what percentage of the population will be more resistant to malaria…

Sickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of the genetic defect. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to survive better than either of the homozygous conditions. 11% of an African population is born with a severe form of sickle-cell anemia (ss), What is the frequency of the recessive allele? Please show your work in order