ORGANIC CHEMISTRY-W/S.G+SOLN.MANUAL
8th Edition
ISBN: 9780134595450
Author: Bruice
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 21, Problem 76P
The primary structure of β-endorphin, a peptide containing 31 amino acids synthesized by the body to control pain, is shown here:
Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-He-He-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu
- a. What fragments are obtained as a result of treatment with each of the following?
1. trypsin
2. cyanogen bromide
3. chymotrypsin
- b. How much of the primary structure can be determined if the amino acids contained in each fragment (but not their sequence ) are known?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Don't used hand raiting
Don't used hand raiting
Don't used hand raiting
Chapter 21 Solutions
ORGANIC CHEMISTRY-W/S.G+SOLN.MANUAL
Ch. 21.1 - a. Explain why, when the imidazole ring of...Ch. 21.2 - a. Which isomer(R)-alanine or (S)-alanineis...Ch. 21.2 - Prob. 4PCh. 21.3 - Prob. 5PCh. 21.3 - Prob. 6PCh. 21.3 - Draw the predominant form for glutamate in a...Ch. 21.3 - a. Why is the pKa of the glutamate side chain...Ch. 21.4 - Calculate the pI of each of the following amino...Ch. 21.4 - a. Which amino acid has the lowest pI value? b....Ch. 21.4 - Prob. 12P
Ch. 21.4 - Prob. 13PCh. 21.4 - Explain why the pI of lysine is the average of the...Ch. 21.5 - What aldehyde is formed when valine is treated...Ch. 21.5 - Prob. 16PCh. 21.5 - Prob. 17PCh. 21.5 - Prob. 18PCh. 21.5 - Prob. 19PCh. 21.6 - Why is excess ammonia used in the preceding...Ch. 21.6 - Prob. 21PCh. 21.6 - What amino acid is formed using the...Ch. 21.6 - Prob. 23PCh. 21.6 - What amino acid is formed when the aldehyde used...Ch. 21.7 - Esterase is an enzyme that catalyzes the...Ch. 21.8 - Draw the tetrapeptide Ala-Thr-Asp-Asn and indicate...Ch. 21.8 - Draw the resonance contributors of the peptide...Ch. 21.8 - Which bonds in the backbone of a peptide can...Ch. 21.9 - An opioid pentapeptide has the following...Ch. 21.9 - What is the configuration about each of the...Ch. 21.9 - Glutathione is a tripeptide whose function is to...Ch. 21.10 - What dipeptides would be formed by heating a...Ch. 21.10 - Suppose you are trying to synthesize the dipeptide...Ch. 21.10 - Show the steps in the synthesis of the...Ch. 21.10 - a. Calculate the overall yield of bradykinin when...Ch. 21.11 - Show the steps in the synthesis of the...Ch. 21.13 - Prob. 37PCh. 21.13 - In determining the primary structure of insulin,...Ch. 21.13 - A decapeptide undergoes partial hydrolysis to give...Ch. 21.13 - Explain why cyanogen bromide does not cleave on...Ch. 21.13 - Indicate the peptides produced from cleavage by...Ch. 21.14 - Prob. 43PCh. 21.14 - Three peptides were obtained from a trypsin...Ch. 21.14 - Prob. 45PCh. 21.15 - How would a protein that resides in the nonpolar...Ch. 21.16 - a. Which would have the greatest percentage of...Ch. 21.17 - When apples that have been cut are exposed to...Ch. 21 - Glycine has pK2 values of 2.34 and 9.60. At what...Ch. 21 - Prob. 50PCh. 21 - A titration curve is a plot of the pH of a...Ch. 21 - Prob. 52PCh. 21 - Aspartame (its structure is on page 1007) has a pl...Ch. 21 - Draw the form of aspartate that predominates at...Ch. 21 - Show how phenylalanine can be prepared by...Ch. 21 - A professor was preparing a manuscript for...Ch. 21 - What aldehydes are formed when the following amino...Ch. 21 - Prob. 58PCh. 21 - Determine the amino acid sequence of a polypeptide...Ch. 21 - Prob. 60PCh. 21 - Prob. 61PCh. 21 - Which is the more effective buffer at...Ch. 21 - Identify the location and type of charge on the...Ch. 21 - Draw the product obtained when a lysine side chain...Ch. 21 - After the polypeptide shown below was treated with...Ch. 21 - Treatment of a polypeptide with 2-mercaptoethanol...Ch. 21 - Show how aspartame can be synthesized using DCCD.Ch. 21 - -Amino acids can be prepared by treating an...Ch. 21 - Reaction of a polypeptide with carboxypeptidase A...Ch. 21 - a. How many different octapeptides can be made...Ch. 21 - Glycine has pKa values of 2.3 and 9.6. Do you...Ch. 21 - A mixture of 15 amino acids gave the fingerprint...Ch. 21 - Write the mechanism for the reaction of an amino...Ch. 21 - Prob. 74PCh. 21 - Show how valine can be prepared by a. a...Ch. 21 - The primary structure of -endorphin, a peptide...Ch. 21 - A chemist wanted to test his hypothesis that the...Ch. 21 - Propose a mechanism for the rearrangement of the...Ch. 21 - A normal polypeptide and a mutant of the...Ch. 21 - Determine the amino acid sequence of a polypeptide...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Similar questions
- Don't used hand raitingarrow_forwardIf a high molecular weight linear polyethylene is chlorinated by inducing the substitution of chlorine atoms by hydrogen, if 5% of all hydrogen atoms are replaced, what approximate percentage of chlorine by weight would the product have?arrow_forwardO Macmillan Learning Chemistry: Fundamentals and Principles Davidson presented by Macmillan Learning Poly(ethylene terephthalate), known as PET or industrially as Dacron, is a polyester synthesized through a condensation reaction between two bifunctional monomers. The monomers, ethylene glycol and terepthalic acid, are given. Add bonds and remove atoms as necessary to show the structure of a two repeat unit portion of a longer polymer chain of PET. You may need to zoom out to see the complete structure of all four monomer units. Select Draw / || | C H 0 3 © Templates More ° ° ° || C CC - OH HO OH HOC - C Erase CC OH HO C C 〃 C H₂ Q2Qarrow_forward
- Q1 - What type(s) of bonding would be expected for each of the following materials: solid xenon, calcium fluoride (CaF2), bronze, cadmium telluride (CdTe), rubber, and tungsten? Material solid xenon CaF2 bronze CdTe rubber tungsten Type(s) of bonding Q2- If the atomic radius of lead is 0.175 nm, calculate the volume of its unit cell in cubic meters.arrow_forwardDetermine the atomic packing factor of quartz, knowing that the number of Si atoms per cm3 is 2.66·1022 and that the atomic radii of silicon and oxygen are 0.038 and 0.117 nm.arrow_forwardUse the following data for an unknown gas at 300 K to determine the molecular mass of the gas.arrow_forward
- 2. Provide a complete retrosynthetic analysis and a complete forward synthetic scheme to make the following target molecule from the given starting material. You may use any other reagents necessary. Brarrow_forward146. Use the following data for NH3(g) at 273 K to determine B2p (T) at 273 K. P (bar) 0.10 0.20 0.30 0.40 0.50 0.60 (Z -1)/10-4 1.519 3.038 4.557 6.071 7.583 9.002 0.70 10.551arrow_forward110. Compare the pressures given by (a) the ideal gas law, (b) the van der Waals equation, and (c) the Redlic-Kwong equation for propane at 400 K and p = 10.62 mol dm³. The van der Waals parameters for propane are a = 9.3919 dm6 bar mol-2 and b = 0.090494 dm³ mol−1. The Redlich-Kwong parameters are A = 183.02 dm bar mol-2 and B = 0.062723 dm³ mol-1. The experimental value is 400 bar.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Introduction to General, Organic and BiochemistryChemistryISBN:9781285869759Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar TorresPublisher:Cengage Learning
Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning
General, Organic, and Biological ChemistryChemistryISBN:9781285853918Author:H. Stephen StokerPublisher:Cengage Learning
Organic And Biological ChemistryChemistryISBN:9781305081079Author:STOKER, H. Stephen (howard Stephen)Publisher:Cengage Learning,
Introduction to General, Organic and Biochemistry
Chemistry
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Cengage Learning
Organic Chemistry
Chemistry
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:Cengage Learning
General, Organic, and Biological Chemistry
Chemistry
ISBN:9781285853918
Author:H. Stephen Stoker
Publisher:Cengage Learning
Organic And Biological Chemistry
Chemistry
ISBN:9781305081079
Author:STOKER, H. Stephen (howard Stephen)
Publisher:Cengage Learning,
Biomolecules - Protein - Amino acids; Author: Tutorials Point (India) Ltd.;https://www.youtube.com/watch?v=ySNVPDHJ0ek;License: Standard YouTube License, CC-BY