Chapter 21, Problem 67P

Interpretation Introduction

Interpretation: The normal and amyloid prion protein is to be differentiated based on their conformation.

Concept introduction:

One of the types of the secondary structure of a protein is $\text{β-pleated}$ a sheet wherein two or more polypeptide chains are situated alongside stabilized by the interchain hydrogen bonds. These strands can be arranged parallel or antiparallel to one another. As there is interchain hydrogen bonding as compared to intrachain hydrogen bonds of another type i.e. $\text{α-helix}$ , the protein aggregates will have more of $\text{β}$ -sheets.