ORGANIC CHEMISTRY-ACCESS
ORGANIC CHEMISTRY-ACCESS
6th Edition
ISBN: 9781260475586
Author: SMITH
Publisher: MCG
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Chapter 21, Problem 65P
Interpretation Introduction

Interpretation: The synthesis of anastrozole from the given compounds is to be devised.

Concept introduction: Alkylation of aldehydes and ketones takes place in the presence of a strong base. The use of appropriate base, solvent and temperature can yield one major product regioselectively.

The first step is abstraction of proton and second step is attack of electrophile to form alkylated product. N-bromosuccinimide in the presence of peroxide undergoes bromination on allylic and benzylic positions.

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