ORGANIC CHEMISTRY (LOOSELEAF)-PACKAGE
ORGANIC CHEMISTRY (LOOSELEAF)-PACKAGE
10th Edition
ISBN: 9781260008562
Author: Carey
Publisher: MCG
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Chapter 21, Problem 55P

The α- methylene ketone sarkomycin has an inhibitory effect on certain types of

tumors. A key step in the synthesis of sarkomycin is the reaction of lactone ester A with potassium tert-butoxide in tetrahydrofuran to give the bicyclic compound B. Write a mechanism for this reaction.

Chapter 21, Problem 55P, The - methylene ketone sarkomycin has an inhibitory effect on certain types of tumors. A key step in

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Don't used hand raiting and don't used Ai solution
I don't understand what to put for final step. Does that just mean termination? And would a radical form when I add bromine to ch2 between the rings?
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