Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Chapter 21, Problem 32CTQ
Prions are responsible for variant Creutzfeldt Jakob Disease, which has resulted in over 100 human deaths in Great Britain during the last 10 years. How do humans contract this disease?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 21 Solutions
Biology 2e
Ch. 21 - Figure 21.5 Which of the following statements...Ch. 21 - Figure 21.8 Influenza virus is packaged in a viral...Ch. 21 - Figure 21.10 Which of the following statements is...Ch. 21 - Which statement is true? A virion contains DNA and...Ch. 21 - The viral______play(s) a role in attaching a...Ch. 21 - Viruses. all have a round shape cannot have a long...Ch. 21 - The observation that the bacteria genus Chlamydia...Ch. 21 - A scientist discovers a new virus with a linear,...Ch. 21 - Which statement is not true of viral replication?...Ch. 21 - Which statement is true of viral replication? In...
Ch. 21 - Which statement is true of reverse transcriptase?...Ch. 21 - Oncogenic virus cores can be. RNA DNA neither RNA...Ch. 21 - Which is true of DNA viruses? They use the host...Ch. 21 - A bacteriophage can infect the lungs viruses...Ch. 21 - People with the CCR5?32 mutation of a T-cell...Ch. 21 - An apple grower notices that several of his apple...Ch. 21 - Which of the following is NOT used to treat active...Ch. 21 - Vaccines. are similar to viroids are only needed...Ch. 21 - A patient presents at the clinic with an acute...Ch. 21 - Which of the following is not associated with...Ch. 21 - Which statement is true of viroids? They are...Ch. 21 - The first electron micrograph of a virus (tobacco...Ch. 21 - Varicella-zoster virus is a double-stranded DNA...Ch. 21 - Classify the Rabies virus (a rhabdovirus family...Ch. 21 - Why can’t dogs catch the measles?Ch. 21 - One of the first and most important targets for...Ch. 21 - In this section, you were introduced to different...Ch. 21 - Although plant viruses cannot infect humans, what...Ch. 21 - A bacteriophage with a lytic life cycle develops a...Ch. 21 - Why is immunization after being bitten by a rabid...Ch. 21 - The vaccine Gardasil that targets human papilloma...Ch. 21 - Prions are responsible for variant Creutzfeldt...Ch. 21 - How are viroids like viruses?Ch. 21 - A botanist notices that a tomato plant looks...
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