Nester's Microbiology: A Human Perspective
Nester's Microbiology: A Human Perspective
8th Edition
ISBN: 9780073522593
Author: Denise G. Anderson Lecturer, Sarah Salm, Deborah Allen
Publisher: McGraw-Hill Education
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Chapter 20, Problem 3SA
Summary Introduction

To review:

The involvement of the penicillin-binding proteins (PBP) in the bacterial susceptibility to β-lactam (beta-lactam) antibiotics.

Introduction:

The β-lactam antibiotics are basically all the antibiotics that share a common feature, which is the presence of a beta-lactam ring in their molecular structures. This puts all of them under thesame category. This group includes all the penicillin derivatives, monobactams, carbapenems, and the cephalosporins. These are generally bactericidal, which means that they kill the bacteria. The PBPs are the enzymes found anchored on the cell membranes and perform a major role in peptidoglycan synthesis.

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