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Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Question
Chapter 20, Problem 20P
Summary Introduction
To determine:
The requirements, methods, and result of the molecular test that can determine whether chemotherapy given to patient would be completely successful or not.
Introduction:
Leukaemia is a white blood cell cancer that takes place in the body of an individual as the result of a reciprocal translocation. Chemotherapy is used for the treatment of leukaemia. In chemotherapy, patients are given drugs that kill the cancer cells, but these drugs may result in many side effects.
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Investigation: Is a dog more closely related to a coyote or a wolf?
Gray Wolf
Species Name: Canis lupus
Color: Light gray to black
Size: 80-120 pounds, 2.5 feet tall
Appearance: broad snout, round ears, long tail
Coyote
Species Name: Canis latrans
Color: Light gray to brown
Size: 20-50 pounds, 1.5 feet tall
Appearance: narrow snout, pointed ears, long tail
Dog, Alaskan Malamute
Species Name: Canis lupus familiaris
Color: Gray and white or brown and white
Size: 70-80 pounds, 2 feet tall
Appearance: broad snout, round ears, long tail
1. Examine the images and descriptions above.
Underline any similarities between the dog and the wolf.
Place a star
next to any coyote traits that are similar to the dog.
2. Based on appearance alone, which do you think is the most closely related to a dog?
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According to a recent study, 1 out of 50,000 people will be diagnosed with
cystic fibrosis. Cystic fibrosis can be caused by a mutant form of the CFTR gene
(dominant gene symbol is F and mutant is f).
A. Using the rate of incidence above, what is the frequency of carriers of the
cystic fibrosis allele for CFTR in the US? (3 pts)
B. In a clinical study, 400 people from the population mentioned in (A.) were
genotyped for BRCA1 Listed below are the results. Are these results in Hardy-
Weinberg equilibrium? Use Chi Square to show whether or not they are. (3 pts)
# of women
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Chapter 20 Solutions
Genetics: From Genes to Genomes
Ch. 20 - For each of the terms in the left column, choose...Ch. 20 - Characterize the differences between tumor cells...Ch. 20 - Prob. 3PCh. 20 - Prob. 4PCh. 20 - A carcinogenic compound is placed on the skin of...Ch. 20 - You have decided to study genetic factors...Ch. 20 - B cells are specialized blood cells that secrete...Ch. 20 - Molecules outside and inside the cell regulate the...Ch. 20 - Put the following steps in the correct ordered...Ch. 20 - a. Would you expect a cell to continue or to stop...
Ch. 20 - Two different protein complexes called SCF and APC...Ch. 20 - One of the hallmarks of mitotic anaphase is the...Ch. 20 - Concerning the Tools of Genetics Box Analysis of...Ch. 20 - Are genome and karyotype instabilities...Ch. 20 - Prob. 15PCh. 20 - Why dont all loss-of-function mutations that are...Ch. 20 - Chromothripsis is a rare phenomenon, first...Ch. 20 - The chromosome 9/22 translocation associated with...Ch. 20 - A female patient 19 years old, whose symptoms are...Ch. 20 - Prob. 20PCh. 20 - A generic signaling cascade is shown in the...Ch. 20 - Neurofibromatosis type 1 NF1; also known as von...Ch. 20 - Families with germ-line BRCA1 or BRCA2...Ch. 20 - The text explained that retroviruses can cause...Ch. 20 - Hepatocellular carcinoma is the most frequent form...Ch. 20 - Suppose that instead of microarrays, you analyzed...Ch. 20 - Prob. 27PCh. 20 - Glioblastoma multiforme GBM is the most common and...Ch. 20 - a. The legend to Fig. 20.29 identifies which of...Ch. 20 - The website CBioPortal http://www.cbioportal.org...
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