HUMAN ANATOMY
6th Edition
ISBN: 9781260210262
Author: SALADIN
Publisher: RENT MCG
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Chapter 20, Problem 20.5.5AYLO
Summary Introduction
To analyze:
The principal categories of heart disease.
Introduction:
Heart disease is one of the most common causes of death worldwide. There are different forms of heart disease. Among them, the most common form of heart disease is coronary atherosclerosis. This form of heart disease often leads tomyocardial infarction. However, there are several other forms of heart disease.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 20 Solutions
HUMAN ANATOMY
Ch. 20.1 - Answer the following questions to test you...Ch. 20.2 - Parts of the fibrous skeleton sometimes become...Ch. 20.2 - Prob. 3BYGOCh. 20.2 - Prob. 4BYGOCh. 20.2 - Answer the following questions to test you...Ch. 20.3 - Answer the following questions to test you...Ch. 20.3 - Prob. 7BYGOCh. 20.3 - Prob. 8BYGOCh. 20.3 - Answer the following questions to test you...Ch. 20.4 - Why should mitochondria be large and more abundant...
Ch. 20.4 - Answer the following questions to test you...Ch. 20.4 - Answer the following questions to test you...Ch. 20.4 - Prob. 12BYGOCh. 20.4 - Prob. 13BYGOCh. 20.4 - Prob. 14BYGOCh. 20.5 - Answer the following questions to test you...Ch. 20.5 - Answer the following questions to test you...Ch. 20.5 - Prob. 17BYGOCh. 20.5 - Answer the following questions to test you...Ch. 20 - Prob. 20.1.1AYLOCh. 20 - Prob. 20.1.2AYLOCh. 20 - Prob. 20.1.3AYLOCh. 20 - To test your knowledge, discuss the following...Ch. 20 - To test your knowledge, discuss the following...Ch. 20 - Prob. 20.1.6AYLOCh. 20 - Prob. 20.2.1AYLOCh. 20 - Prob. 20.2.2AYLOCh. 20 - Prob. 20.2.3AYLOCh. 20 - Reasons for the differences in muscularity between...Ch. 20 - Prob. 20.2.5AYLOCh. 20 - Prob. 20.2.6AYLOCh. 20 - The names, locations, and anatomy of the two...Ch. 20 - Prob. 20.2.8AYLOCh. 20 - Prob. 20.2.9AYLOCh. 20 - Prob. 20.2.10AYLOCh. 20 - Prob. 20.3.1AYLOCh. 20 - Prob. 20.3.2AYLOCh. 20 - Prob. 20.3.3AYLOCh. 20 - Prob. 20.3.4AYLOCh. 20 - Prob. 20.4.1AYLOCh. 20 - Prob. 20.4.2AYLOCh. 20 - Prob. 20.4.3AYLOCh. 20 - The Coronary Conduction System and Cardiac...Ch. 20 - Prob. 20.4.5AYLOCh. 20 - Prob. 20.5.1AYLOCh. 20 - Prob. 20.5.2AYLOCh. 20 - Prob. 20.5.3AYLOCh. 20 - Prob. 20.5.4AYLOCh. 20 - Prob. 20.5.5AYLOCh. 20 - Prob. 1TYRCh. 20 - To get from the right atrium to the right...Ch. 20 - There is/are_________ pulmonary vein(s) emptying...Ch. 20 - Prob. 4TYRCh. 20 - Prob. 5TYRCh. 20 - These are some of the points that the blood passes...Ch. 20 - The ascending aorta and pulmonary trunk develop...Ch. 20 - Prob. 8TYRCh. 20 - Blood in the anterior interventricular branch of...Ch. 20 - Which of these is not characteristic of the heart...Ch. 20 - Prob. 11TYRCh. 20 - The circulatory route from aorta to the venae...Ch. 20 - The circumflex branch of the left coronary artery...Ch. 20 - The finest passages through which electical...Ch. 20 - Electrical signal pass quickly from one...Ch. 20 - The abnormal bulging of the left AV valve into the...Ch. 20 - Prob. 17TYRCh. 20 - Prob. 18TYRCh. 20 - Prob. 19TYRCh. 20 - Prob. 20TYRCh. 20 - Prob. 1BYMVCh. 20 - Prob. 2BYMVCh. 20 - Prob. 3BYMVCh. 20 - Prob. 4BYMVCh. 20 - Prob. 5BYMVCh. 20 - Prob. 6BYMVCh. 20 - Prob. 7BYMVCh. 20 - Prob. 8BYMVCh. 20 - Prob. 9BYMVCh. 20 - Prob. 10BYMVCh. 20 - Prob. 1WWWTSCh. 20 - Prob. 2WWWTSCh. 20 - Prob. 3WWWTSCh. 20 - Briefly explain why each of the following...Ch. 20 - Briefly explain why each of the following...Ch. 20 - Prob. 6WWWTSCh. 20 - Briefly explain why each of the following...Ch. 20 - Prob. 8WWWTSCh. 20 - Prob. 9WWWTSCh. 20 - Prob. 10WWWTSCh. 20 - Prob. 1TYCCh. 20 - Becky, age 2, was born with a hole in her...Ch. 20 - Prob. 3TYCCh. 20 - Prob. 4TYCCh. 20 - Prob. 5TYC
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