Human Anatomy (8th Edition)
8th Edition
ISBN: 9780134243818
Author: Elaine N. Marieb, Patricia Brady Wilhelm, Jon B. Mallatt
Publisher: PEARSON
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Chapter 20, Problem 19RQ
Summary Introduction
To review:
The sinusoid and an organ containing fenestrated capillaries.
Introduction:
The capillaries are the smallest and most important blood vessels of the human body. They are made up of a single layer of endothelial cells covered by a basement membrane. They provide oxygen and nutrients to the tissue and also have site-specific functions, such as uptake of digested food from the small intestine.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 20 Solutions
Human Anatomy (8th Edition)
Ch. 20 - What structural features of capillaries make them...Ch. 20 - Prob. 2CYUCh. 20 - Prob. 3CYUCh. 20 - Prob. 4CYUCh. 20 - Prob. 5CYUCh. 20 - Prob. 6CYUCh. 20 - Which vessel do you palpate to feel a pulse in...Ch. 20 - Name the vessels that branch off the abdominal...Ch. 20 - Prob. 9CYUCh. 20 - Prob. 10CYU
Ch. 20 - Prob. 11CYUCh. 20 - Prob. 12CYUCh. 20 - How does elevated blood glucose associated with...Ch. 20 - Prob. 14CYUCh. 20 - Prob. 15CYUCh. 20 - Prob. 1RQCh. 20 - Prob. 2RQCh. 20 - Prob. 3RQCh. 20 - Prob. 4RQCh. 20 - Which of the following vessels is bilaterally...Ch. 20 - Prob. 6RQCh. 20 - Prob. 7RQCh. 20 - Prob. 8RQCh. 20 - The following sequence traces the flow of...Ch. 20 - Prob. 10RQCh. 20 - The inferior mesenteric artery supplies the (a)...Ch. 20 - Prob. 12RQCh. 20 - Prob. 13RQCh. 20 - Prob. 14RQCh. 20 - Prob. 15RQCh. 20 - Prob. 16RQCh. 20 - (a) What structural features are responsible for...Ch. 20 - Prob. 18RQCh. 20 - Prob. 19RQCh. 20 - Sketch the arterial circle at the base of the...Ch. 20 - Prob. 21RQCh. 20 - Prob. 22RQCh. 20 - Prob. 23RQCh. 20 - Prob. 24RQCh. 20 - Differentiate between arteriosclerosis and...Ch. 20 - A pulse can be felt in the following arteries:...Ch. 20 - In an eighth-grade health class, the teacher...Ch. 20 - Prob. 2CRCAQCh. 20 - Prob. 3CRCAQCh. 20 - Prob. 4CRCAQCh. 20 - Prob. 5CRCAQCh. 20 - Prob. 6CRCAQCh. 20 - Occasionally, either the ductus arteriosus or the...Ch. 20 - Prob. 8CRCAQ
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