ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260406092
Author: HARTWELL, Leland, HOOD, Leroy, Goldberg, Michael
Publisher: Mcgraw-hill Education/stony Brook University
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Chapter 20, Problem 12P

One of the hallmarks of mitotic anaphase is the separation of sister chromatids. A protein complex called cohesin holds sister chromatids together, as described in Fig. 12.25. Based on the answer you have just given for Problem 11, propose a mechanism that would allow sister chromatids to separate during anaphase. How might your proposed mechanism also explain the checkpoint operating in M phase that prevents sister chromatid separation until all the chromosomes have connected properly to the mitotic spindle?

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ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES

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