Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 2, Problem 49P
Go to the OMIM website (http://www.ncbi.nlm.nih.gov/ omim) and locate the Search button at the top of the page. Use the Search function to look up, one by one, the following three human hereditary diseases that are relatively common in certain populations: “Tay–Sachs disease” (select OMIM number 272800 from the search results list); “cystic fibrosis” (select OMIM number 602421 from the search results list); and “sickle cell anemia” (select OMIM 603903 from the search results list). For each of these diseases, look through the information and provide the following details:
a. On which chromosome is the gene for the disease located?
b. What gene is mutated in the disease?
c. Briefly describe the disease.
d. In which population(s) does the disease most commonly occur?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Jonah and Jana are siblings. Jonah has the genetic disorder cystic fibrosis, caused by inheriting one copy from each parent of a mutation in the CF gene. Jana does not have cystic fibrosis. Which of the following statements is/are true? (Select all that are true)
a)Jana does not have the gene that when mutant causes cystic fibrosis.
b)Jana has the gene that when mutant causes cystic fibrosis.
c)Jana has two copies of the allele that causes cystic fibrosis.
d)Jana does not have two copies of the allele that causes cystic fibrosis.
Niemann Pick Type C disease is a recessive disorder that causes the accumulation of cholesterol and other lipids in lysosomes, ultimately affecting both the liver and the nervous system. Below are the genotypes and phenotypes of offspring of a family with a history of Niemann Pick.
7 NN ( all normal phenotype)
3 Nn (all normal phenotype)
4 nn (1 early onset dementia, 1 mid-life onset dementia, 2 late-onset dementia).
From this information, Niemann-Pick disease is an example of:
A) variable expressivity
B) incomplete dominance
C) incomplete penetrance
D) variable expressivity and incomplete penetrance
E) multiple alleles
what is the diagnosis of Chronic granulomatous disease (CGD) and explain the genetic mechanism involved. *do not plagiarized*
Chapter 2 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 2 -
1. Compare and contrast the following terms:
a....Ch. 2 - For the cross , what is the expected genotype...Ch. 2 - 37. Galactosemia is an autosomal recessive...Ch. 2 - In mice, black coat color is dominant to white...Ch. 2 - Two parents plan to have three children. What is...Ch. 2 - Consider the cross AaBbCCAABbCc. a. How many...Ch. 2 - If a chi-square test produces a chi-square value...Ch. 2 -
8. Determine whether the statements below are...Ch. 2 - In the datura plant, purple flower color is...Ch. 2 - 10. The dorsal pigment pattern of frogs can be...
Ch. 2 - 11. Black skin color is dominant to pink skin...Ch. 2 - A male mouse with brown fur color is mated to two...Ch. 2 - 13. Figure 2.12 shows the results of Mendel’s...Ch. 2 - 14. An experienced goldfish breeder receives two...Ch. 2 -
15. The accompanying pedigree shows the...Ch. 2 -
16. A geneticist crosses a pure-breeding strain...Ch. 2 - Suppose an F1 plant from Problem 16 is crossed to...Ch. 2 - 18. In pea plants, the appearance of flowers along...Ch. 2 - 19. If two six-sided dice are rolled, what is the...Ch. 2 - Experimental Insight 2.1 describes data, collected...Ch. 2 -
21. The accompanying pedigree shows the...Ch. 2 - 22. The seeds in bush bean pods are each the...Ch. 2 - List all the different gametes that are possible...Ch. 2 - Organisms with the genotypes AABbCcDd and AaBbCcDd...Ch. 2 - 25. Blue moon beans produce beans that are either...Ch. 2 - In the fruit fly Drosophila, a rudimentary wing...Ch. 2 - In pea plants, plant height, seed shape, and seed...Ch. 2 - A variety of pea plant called Blue Persian...Ch. 2 - 29. In tomato plants, the production of red fruit...Ch. 2 - A male and a female are each heterozygous for both...Ch. 2 - A woman expressing a dominant phenotype is...Ch. 2 - Two parents who are each known to be carriers of...Ch. 2 - 33. An organism having the genotype AaBbCcDdEe is...Ch. 2 - 34. A man and a woman are each heterozygous...Ch. 2 - For a single dice roll, there is a 16 chance that...Ch. 2 - You have four guinea pigs for a genetic study. One...Ch. 2 - 37. Galactosemia is an autosomal recessive...Ch. 2 - Sweet yellow tomatoes with a pear shape bring a...Ch. 2 - A cross between a spicy variety of Capsicum annum...Ch. 2 - Alkaptonuria is an infrequent autosomal recessive...Ch. 2 - 41. Humans vary in many ways from one another....Ch. 2 - 42. In chickens, the presence of feathers on the...Ch. 2 -
43. A pure-breeding fruit fly with the...Ch. 2 - 44. Situs inversus is a congenital condition in...Ch. 2 - 45. Domestic dogs evolved from ancestral grey...Ch. 2 - Alleles of the IGF-1 gene in dogs, encoding...Ch. 2 - 47. The accompanying pedigree shows a family in...Ch. 2 -
48. A pea plant that has the genotype RrGgwwdd is...Ch. 2 - Go to the OMIM website...Ch. 2 - Prob. 50PCh. 2 - Prob. 51PCh. 2 -
52. In humans, the ability to bend the thumb...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- What is the genetic basis and phenotype for each of the following disorders (use proper genetic notation)? a. Edwards syndrome b. Patau syndrome c. Klinefelter syndrome d. Down syndromearrow_forwardPlease solvearrow_forwardSelect two of the following diseases and discuss cause, predisposing factors and identify if it is considered a Genetic Disease or a Congenital defect: 1) Phenylketonuria 2) Cystic fibrosisarrow_forward
- Can you help me to explain to me because i struggled with my homework?arrow_forwardA 22-year-old man enters the clinic with a wide-stepping gait, muscle wasting, myotonia, and bilateral cataracts. His father, who is 55, currently suffers from similar symptoms, which began about 5 years ago. His father's sister also exhibits similar symptoms; hers also began in her 50s. The patient's mother exhibits none of these symptoms. What is the inheritance pattern of this patient's most likely disease?arrow_forwardHuntington disease (HD) is a genetic disorder that usually first appears in middle age and, over time, leads to involuntary movements, impaired speech, difficulty swallowing and speaking, and cognitive decline. There is no cure for HD, and affected individuals eventually die, usually after 10 to 15 years of progressively worsening symptoms. Huntington disease is inherited as an autosomal dominant disorder. Presymptomatic genetic testing for HD is available for people with a family history of the disease. Individuals who have a parent with HD have a 50% chance of inheriting the HD gene and eventually having HD. Some of these individuals want to know if they will eventually get the disease, and they undergo presymptomatic genetic testing. Others do not want to know, given that there is no cure or effective treatment for the disease. If you were at risk for HD, would you want to undergo genetic testing? What are some reasons for and against having a genetic test for HD?arrow_forward
- What genes are involved in Gaucher disease? Is the sequence of the gene known? Is genetic testing recommended for Gaucher disease? Give typing answer with explanation and conclusionarrow_forwardTuberous Sclerosis (TS) is an autosomal dominant genetic disease characterized by seizures, mental retardation, autism, and benign tumors of the brain, heart, skin, and kidneys. The kidney tumors can also be malignant. This disease exhibits a wide range of severity, and only about 1/3 of the cases are inherited. Two different genes have been tightly linked to the disease in families where it is inherited. The remaining 2/3 appear to be due to mutations in one of the 2 genes as well. Overall it appears that 1/2 are caused by mutations in TSC1 and the other half by mutations in TSC2. A rat model for hereditary renal carcinoma (kidney cancer) has been found. Southern and Northern blot analysis of the TSC1 and TSC2 gene revealed no differences between these rats and normal rats. Not all the rats in the strain would get cancer but a significant proportion did and those were selected for and used in experiments. 1. a) What was detected by the Southern blots? (look this up, make your…arrow_forwardCan you think of other respiratory diseases that are directly affected by the Cystic Fibrosis gene? Describe its effects on the body and how it correlates with cystic fibrosis. Be sure to include a scholarly source.arrow_forward
- please answer in depth, minimum 500 wordsarrow_forwardNeurofibromatosis type 1 (NF1) is an inherited is an inheritent dominant disorder. The phenotype usually involves the production of many skin neurofibromas. Answer the following question about the disorder: The rarer form of neurofibromatosis is called segmental neurofibromatosis. In this form of the disease, neither parent of the patient has any clinical sign of the disease, and the tumors in the patient are restricted to one part of the body. Suggest an explanation for the genesis of segmental neurofibromatosis that clarifies why it is restricted to one part of the body.arrow_forwardWe often speak of diseases such as phenylketonuria (PKU) andachondroplasia as having a genetic basis. Explain whether the followingstatements are accurate with regard to the genetic basis ofany human disease (not just PKU and achondroplasia).A. An individual must inherit two copies of a mutant allele to havedisease symptoms.B. A genetic predisposition means that an individual has inheritedone or more alleles that make it more likely that she or he willdevelop disease symptoms than other individuals in a populationwill.C. A genetic predisposition to develop a disease may be passedfrom parents to offspring.D. The genetic basis for a disease is always more important thanthe environment.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
How to solve genetics probability problems; Author: Shomu's Biology;https://www.youtube.com/watch?v=R0yjfb1ooUs;License: Standard YouTube License, CC-BY
Beyond Mendelian Genetics: Complex Patterns of Inheritance; Author: Professor Dave Explains;https://www.youtube.com/watch?v=-EmvmBuK-B8;License: Standard YouTube License, CC-BY