Biochemistry: Concepts and Connections
1st Edition
ISBN: 9780321839923
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 19, Problem 6P
Interpretation Introduction
Interpretation:
Leukemia is a neoplastic (cancerous) proliferation of white blood cells. Clinicians are currently testing deoxycoformycin, an adenosine deaminase inhibitor, as a possible antileukemic agent. The reason this therapy is effective.
Concept Introduction:
2'-deoxycoformycin (dCF) is an inhibitor of adenosine deaminase. dCF targets leukemia, myeloid, erythroid and lymphoma cells for apoptosis in the presence of either 2'-deoxyadenosine (dAdo) or its analog adenine arabinoside (araA).
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Biochemistry: Concepts and Connections
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