Biochemistry: Concepts and Connections
1st Edition
ISBN: 9780321839923
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 19, Problem 15P
Interpretation Introduction
Interpretation:
Conversion of hydroxy methyl group of 10- formyltetrahydrofolate with help of purinosome should be identified.
Concept introduction:
The purinosome is an enzyme that catalysis purine biosynthesis within the cell. The 10-formyltetrahydrofolate contains hydroxymethyl group at the terminal which get reduced to formyl group with the help of enzyme purinosome.
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Consider the reaction:
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Classify each phrase as describing kinases, phosphatases, neither, or both.
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Answer Bank
transfer phosphoryl groups to acidic amino acids in eukaryotes
may use ATP as a phosphoryl group donor
remove phosphoryl groups from proteins
catalyze reactions that are the reverse of dephosphorylation reactions
regulate the activity of other proteins
catalyze phosphorylation reactions
PKA as an example
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kp
S P
kg
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AG for the reaction increases.
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The concentration of the reactants is increased.
The activation energy for the reaction is lowered.
The formation of the transition state is promoted.
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Biochemistry: Concepts and Connections
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