Biology: The Unity and Diversity of Life
15th Edition
ISBN: 9780357093795
Author: STARR
Publisher: CENGAGE LEARNING (CUSTOM)
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Chapter 19, Problem 4DAA
Antibiotic Effects on Mitochondria Tetracyclines are antibiotics that inactivate bacterial ribosomes. Knowing that mitochondria evolved from bacteria, researchers suspected tetracyclines might affect mitochondria by harming their ribosomes. FIGURE 19. 11 shows the effects of an experiment in which mice were given either tetracycline or a control antibiotic that affects cell wall production. After 10 days of treatment, the function of mitochondria in the mice was assessed.
FIGURE 19.11 Effects of tetracycline on mitochondria. Mice received low-dose tetracycline, high-dose tetracycline, or a control antibiotic that targets bacterial cell walls. Mitochondrial function was assessed by looking at oxygen consumption rate and ATP content in homogenized mouse livers. Bar graphs show means with standard error. An * indicates a statistically significant difference between the experimental and the control treatments.
Do these results support the hypothesis that tetracyclines impair mitochondrial function?
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Shown above is a schematic diagram of the E. coli leader peptidase (Lep) which has several basic amino acids in a cytoplasmic loop. Propose a mutant of Lep that
would be a test of the "inside positive" rule for the orientation of proteins in membranes.
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your answer.
terminal
reversed
same
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1. Make mutant Lep that substitutes noncharged residues for the
chains in the loop, and put
charged side chains in
2. If the inside-positive rule applies, the mutant ought to have the
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Chapter 19 Solutions
Biology: The Unity and Diversity of Life
Ch. 19 - Antibiotic Effects on Mitochondria Tetracyclines...Ch. 19 - Antibiotic Effects on Mitochondria Tetracyclines...Ch. 19 - Antibiotic Effects on Mitochondria Tetracyclines...Ch. 19 - Antibiotic Effects on Mitochondria Tetracyclines...Ch. 19 - Which of the following is NOT true of conditions...Ch. 19 - An abundance of _______ in Earth's early...Ch. 19 - Stanley Miller's experiment demonstrated that...Ch. 19 - According to one hypothesis, negatively charged...Ch. 19 - The prevalence of _______ in living organisms is...Ch. 19 - Prob. 6SQ
Ch. 19 - Among prokaryotes, only the cyanobacteria _______....Ch. 19 - The evolution of _______ resulted in the eventual...Ch. 19 - Evolution of _______ increased the energy...Ch. 19 - Infoldings of the plasma membrane into the...Ch. 19 - The host cell in the endosymbiosis that produced...Ch. 19 - A stromatolite is a structure __________ . a....Ch. 19 - Prob. 13SQCh. 19 - Which of the following events did NOT occur during...Ch. 19 - Chronologically arrange the evolutionary events,...Ch. 19 - Researchers looking for fossils of the earliest...Ch. 19 - The astronomer Carl Sagan once said, "We are made...Ch. 19 - How did the evolution of oxygen-releasing...Ch. 19 - Just as all life shares a last universal common...
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