Fundamentals of Anatomy & Physiology Plus Mastering A&P with eText - Access Card Package (10th Edition) (New A&P Titles by Ric Martini and Judi Nath)
10th Edition
ISBN: 9780321908599
Author: Frederic H. Martini, Judi L. Nath, Edwin F. Bartholomew
Publisher: PEARSON
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Chapter 19, Problem 21CP
List the three primary functions of platelets.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 19 Solutions
Fundamentals of Anatomy & Physiology Plus Mastering A&P with eText - Access Card Package (10th Edition) (New A&P Titles by Ric Martini and Judi Nath)
Ch. 19 - List five major functions of blood.Ch. 19 - 2. Identify the composition of the formed elements...Ch. 19 - Prob. 3CPCh. 19 - Prob. 5CPCh. 19 - Prob. 4CPCh. 19 - What would be the effects of a decrease in the...Ch. 19 - Prob. 7CPCh. 19 - Prob. 9CPCh. 19 - Prob. 10CPCh. 19 - How would liver disease affect the level of...
Ch. 19 - Prob. 8CPCh. 19 - Prob. 12CPCh. 19 - Prob. 13CPCh. 19 - Prob. 14CPCh. 19 - Prob. 15CPCh. 19 - Prob. 16CPCh. 19 - Prob. 17CPCh. 19 - Prob. 18CPCh. 19 - Prob. 19CPCh. 19 - Prob. 20CPCh. 19 - List the three primary functions of platelets.Ch. 19 - Prob. 22CPCh. 19 - Prob. 23CPCh. 19 - Prob. 24CPCh. 19 - Prob. 1RQCh. 19 - The formed elements of the blood include (a)...Ch. 19 - Prob. 3RQCh. 19 - Prob. 4RQCh. 19 - Prob. 5RQCh. 19 - Prob. 6RQCh. 19 - Prob. 7RQCh. 19 - Stem cells responsible for lymphocytopoiesis are...Ch. 19 - ______ and _______ affect almost every aspect of...Ch. 19 - Prob. 10RQCh. 19 - Prob. 11RQCh. 19 - Prob. 12RQCh. 19 - Prob. 13RQCh. 19 - Prob. 14RQCh. 19 - Prob. 15RQCh. 19 - Prob. 16RQCh. 19 - Prob. 17RQCh. 19 - Prob. 18RQCh. 19 - Prob. 19RQCh. 19 - Prob. 20RQCh. 19 - Prob. 21RQCh. 19 - Prob. 22RQCh. 19 - Prob. 23RQCh. 19 - Prob. 24RQCh. 19 - Prob. 25RQCh. 19 - Relate the structure of hemoglobin to its...Ch. 19 - Prob. 27RQCh. 19 - Prob. 28RQCh. 19 - Prob. 29RQCh. 19 - Prob. 30RQCh. 19 - Prob. 31RQCh. 19 - Prob. 1CCCh. 19 - Prob. 2CC
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