Chapter 19, Problem 19.65P

Interpretation Introduction

Interpretation:

For the given reaction, missing intermediate and reagents are to be determined.

Concept introduction:

The ${\text{PBr}}_{\text{3}}$ reagent is used to convert the primary and secondary alcohol to alkyl bromide. Alkyl bromide reacts with magnesium in the presence of ether to give alkyl magnesium bromide as Grignard reagent. LDA is a strong base and makes the base more selective for removing a proton from the less hindered alpha carbon of the ketone. Lithium dialkylcuprate compounds react via conjugate addition.