Chapter 19, Problem 19.22P

Interpretation Introduction

Interpretation:

It is to be shown how to carry out the given synthesis.

Concept introduction:

An organometallic compound has a polar covalent $\text{C-M}$ bond. For example, the Grignard reagent ($\text{RMgX}$) has a polar $\text{C-Mg}$ bond. Since carbon is bonded with an electropositive element, it possesses partial negative charge and acts as a nucleophile as well as a base and can be treated as ${\text{C}}^{\text{-}}$. To protect an alcoholic group, it is converted to its silyl ether derivatives like OTBDMS, which is stable under the basic condition or through other protecting groups.