Chapter 19, Problem 19.53P

Interpretation Introduction

Interpretation:

How to carry out the given synthesis is to be shown.

Concept introduction:

A protecting group temporarily converts a functional group into one that is unreactive under the conditions necessary for a step in the synthesis. Ketones, aldehydes, and alcohols can often be protected in the form of an acetal or ether. Silyl ether derivatives like TBDMSCl are used to protect the OH group; reactivity of ketones and alcohols is similar. The $\text{C=O}$ group of the aldehyde and ketones is protected by treating it with ethylene glycol ${\text{(HOCH}}_{\text{2}}{\text{CH}}_{\text{2}}\text{OH)}$ under acidic condition. A Grignard reagent can add the alkyl group to the electrophilic C atom.