The structure and stereochemistry of the alcohol that would result if 1, 2-epoxycyclohexane was reduced with Lithium aluminium deuteride are to be shown. Concept introduction: The nucleophilic attack of the deuderide ion on the epoxide will yield an alcohol. The attack takes places by S N 2 like backside attack. When both epoxide carbons are either primary or secondary the nucleophilic attack mainly occurs at the less highly substituted side. When one of the epoxide carbons is tertiary, the nucleophilic attack mainly occurs at the more highly substituted side. To give: The structure and stereochemistry of the alcohol that would result if 1, 2-epoxycyclohexane was reduced with Lithium aluminium deuteride.

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Recent advancements in liquid chromatography include the development of ultrahigh pressure liquid chromatography (UHPLC) and an increased use of capillary columns that had previously only been used with gas chromatography. Both of these advances have made the development of portable LC systems possible. For example, Axcend Corp. makes a portable system that uses a capillary column with an internal diameter of 150-μm-that is packed with 1.7-um stationary phase particles. In contrast, a traditional LC column has a 4.6 mm internal diameter and utilizes 5-um stationary phase particles. a) Explain one advantage that is afforded by the use of a capillary column in liquid chromatographic separation. Explain one disadvantage of capillary columns. b) Explain how the use of smaller stationary phase particles can improve the resolution of a separation. Include any relevant equations that support your explanation. c) A scientist at Rowan University is using the Axcend LC to conduct analyses of F…

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Question

Chapter 18.SE, Problem 52AP

Interpretation Introduction

Interpretation:

The structure and stereochemistry of the alcohol that would result if 1, 2-epoxycyclohexane was reduced with Lithium aluminium deuteride are to be shown.

Concept introduction:

The nucleophilic attack of the deuderide ion on the epoxide will yield an alcohol. The attack takes places by S_N² like backside attack. When both epoxide carbons are either primary or secondary the nucleophilic attack mainly occurs at the less highly substituted side. When one of the epoxide carbons is tertiary, the nucleophilic attack mainly occurs at the more highly substituted side.

To give:

The structure and stereochemistry of the alcohol that would result if 1, 2-epoxycyclohexane was reduced with Lithium aluminium deuteride.

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