HUMAN ANA.+PHYS.W/LAB MANUAL >BCI<
19th Edition
ISBN: 9780135672990
Author: AMERMAN
Publisher: Pearson Custom Publishing
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Question
Chapter 18.1, Problem 4QC
Summary Introduction
To review:
The basic properties of elastic arteries, muscular arteries, and arterioles.
Introduction:
Arteries are the type of blood vessels that are responsible for carrying the blood from the heart to the organs. They are distributive in nature. The arteries control blood flow to the organs. They have a thicker layer of tunica media.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 18 Solutions
HUMAN ANA.+PHYS.W/LAB MANUAL >BCI<
Ch. 18.1 - Define the three types of blood vessels in the...Ch. 18.1 - Prob. 2QCCh. 18.1 - Prob. 3QCCh. 18.1 - Prob. 4QCCh. 18.1 - Prob. 5QCCh. 18.1 - 6. How do veins differ structurally and...Ch. 18.1 - Prob. 7QCCh. 18.1 - What are venous valves, and what are their...Ch. 18.1 - Prob. 9QCCh. 18.2 - Prob. 1QC
Ch. 18.2 - Prob. 2QCCh. 18.2 - Prob. 3QCCh. 18.2 - Prob. 4QCCh. 18.2 - Prob. 5QCCh. 18.2 - Prob. 6QCCh. 18.2 - 7. How does mean arterial pressure differ from...Ch. 18.2 - Prob. 8QCCh. 18.2 - Prob. 9QCCh. 18.3 - Prob. 1QCCh. 18.3 - Prob. 2QCCh. 18.3 - Prob. 3QCCh. 18.3 - Prob. 4QCCh. 18.3 - Prob. 5QCCh. 18.3 - Prob. 6QCCh. 18.3 - Prob. 7QCCh. 18.3 - 8. What is circulatory shock, and why is it...Ch. 18.4 - Describe the structure and size of a typical...Ch. 18.4 - 2. List three ways in which substances may cross...Ch. 18.4 - 3. Describe the properties of the three types of...Ch. 18.4 - 4. What is tissue perfusion?
Ch. 18.4 - Prob. 5QCCh. 18.4 - Prob. 6QCCh. 18.4 - Prob. 7QCCh. 18.4 - Prob. 8QCCh. 18.4 - Prob. 9QCCh. 18.5 - What is hydrostatic pressure? How does hydrostatic...Ch. 18.5 - 2. In which direction does the hydrostatic...Ch. 18.5 - 3. What is colloid osmotic pressure? In which...Ch. 18.5 - Prob. 4QCCh. 18.5 - Where in the capillary does net filtration take...Ch. 18.5 - Prob. 6QCCh. 18.6 - List the three branches of the aortic arch.Ch. 18.6 - Prob. 2QCCh. 18.6 - 3. What is the cerebral arterial circle, and what...Ch. 18.6 - Prob. 4QCCh. 18.6 - Which arteries supply the anterior and posterior...Ch. 18.6 - Prob. 6QCCh. 18.6 - Which artery supplies the upper limb?Ch. 18.6 - Trace the arterial supply of the upper limb from...Ch. 18.6 - 9. Which artery supplies the lower limb?
Ch. 18.6 - Trace the arterial supply of the lower limb from...Ch. 18.6 - Prob. 11QCCh. 18.7 - Where do most veins superior to the diaphragm...Ch. 18.7 - Prob. 2QCCh. 18.7 - Where are the dural sinuses located? What drains...Ch. 18.7 - How does drainage of the posterior body wall...Ch. 18.7 - 5. Which abdominal vessels drain straight into...Ch. 18.7 - Prob. 6QCCh. 18.7 - Prob. 7QCCh. 18.7 - Prob. 8QCCh. 18.7 - Prob. 9QCCh. 18.7 - Prob. 10QCCh. 18 - Prob. 1CYRCh. 18 - Locations where vessels connect via collateral...Ch. 18 - 3. The carotid sinus contains:
a....Ch. 18 - 4. Which of the following factors would increase...Ch. 18 - Which of the following would produce a decrease in...Ch. 18 - Fill in the blanks: The two pressures within the...Ch. 18 - The lowest pressure in the systemic circuit occurs...Ch. 18 - Explain the mechanisms that assist in the return...Ch. 18 - Mark the following statements as true or false. If...Ch. 18 - Prob. 10CYRCh. 18 - Capillaries consist of: a. three thin tunics. b....Ch. 18 - List three ways in which substances can cross the...Ch. 18 - Which of the following structures is the leakiest?...Ch. 18 - Prob. 14CYRCh. 18 - 15. The hydrostatic pressure gradient drives water...Ch. 18 - Prob. 16CYRCh. 18 - Match the following arteries with the correct...Ch. 18 - Which of the following is not a common pulse...Ch. 18 - 19. Which of the following vessels does not drain...Ch. 18 - Match the following veins with the correct...Ch. 18 - 1. Explain why a severed artery spurts blood,...Ch. 18 - 2. Explain why a person who is 7 feet tall is...Ch. 18 - Prob. 3CYUCh. 18 - Prob. 1AYKACh. 18 - 2. Mr. Gupta has been diagnosed with nephrotic...Ch. 18 - Predict the effects of each of the following on...Ch. 18 - Prob. 4AYKBCh. 18 - Ms. Rodgers has been diagnosed with secretion of...
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