NESTER'S MICROBIOLOGY-CONNECT >CUSTOM<
9th Edition
ISBN: 9781265432287
Author: Anderson
Publisher: MCG CUSTOM
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Chapter 18, Problem 5MC
Summary Introduction
Introduction:
Attenuated vaccines are the vaccines that are generated using live weakened pathogens that elicit an immune response in the recipient’s body. The attenuated pathogen causes a weak infection in the recipient’s body, which cannot be usually detected. It induces an immune response in the recipient’s body and imparts active immunity. Attenuated vaccines provide a long-term immunity. Attenuated microorganisms are generated by growing them under diverse conditions due to which mutations are accumulated, which make them less pathogenic.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 18 Solutions
NESTER'S MICROBIOLOGY-CONNECT >CUSTOM<
Ch. 18 - How is immune globulin different from hyperimmune...Ch. 18 - Describe two advantages of an attenuated vaccine...Ch. 18 -
3. Describe two advantages of an inactivated...Ch. 18 - Prob. 4SACh. 18 - Prob. 5SACh. 18 - Prob. 6SACh. 18 - Prob. 7SACh. 18 - What is an advantage of the fluorescent antibody...Ch. 18 - Is blood typing an example of a precipitation...Ch. 18 - Prob. 10SA
Ch. 18 - Prob. 1MCCh. 18 - Prob. 2MCCh. 18 - Prob. 3MCCh. 18 - Prob. 4MCCh. 18 - Prob. 5MCCh. 18 - Haemophilus influenzae is an encapsulated...Ch. 18 -
7. In quantifying antibodies in a patient's...Ch. 18 - Prob. 8MCCh. 18 - Prob. 9MCCh. 18 - Prob. 10MCCh. 18 - A new parent asks you which vaccines the CDC...Ch. 18 - Prob. 2ACh. 18 - Prob. 1CTCh. 18 - Prob. 2CT
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