
(a) Interpretation:
Substrate required by B enzyme should be identified.
Concept Introduction:
Biosynthesis of vitamin B12 or cobalamin has aerobic and anaerobic pathways. Aerobic is where the chemical pathway needs oxygen and later cobalt is added. In anaerobic pathway, cobalt is added in the beginning and requires no oxygen.Biosynthesis of B12 as shown in the diagram produces 5-methyltetrahydrofolate as substrate. And methylmalonate is the compound formed in genetic deficient animal's urine. When the C enzyme loses its affinity towards a substrate injecting large amount of Vitamin B12 is reduced. Homocysteine is released during urine excretion.
(b) Interpretation:
Compound excreted in urine because ofenzyme C deficiency in animals should be identified.
Concept Introduction:
Biosynthesis of vitamin B12 or cobalamin has aerobic and anaerobic pathways. Aerobic is where the chemical pathway needs oxygen and later cobalt is added. In anaerobic pathway, cobalt is added in the beginning and requires no oxygen. Biosynthesis of B12 as shown in the diagram produces 5-methyltetrahydrofolate as substrate. And methylmalonate is the compound formed in genetic deficient animal's urine. When the C enzyme loses its affinity towards a substrate injecting large amount of Vitamin B12 is reduced. Homocysteine is released during urine excretion.
(c) Interpretation:
Consistent alterations of genetic in the enzyme because of treatment by injecting B12 for the enzyme C deficiency in animals should be identified.
Concept Introduction:
Biosynthesis of vitamin B12 or cobalamin has aerobic and anaerobic pathways. Aerobic is where the chemical pathway needs oxygen and later cobalt is added. In anaerobic pathway, cobalt is added in the beginning and requires no oxygen. Biosynthesis of B12 as shown in the diagram produces 5-methyltetrahydrofolate as substrate. And methylmalonate is the compound formed in genetic deficient animal's urine. When the C enzyme loses its affinity towards a substrate injecting large amount of Vitamin B12 is reduced. Homocysteine is released during urine excretion.
(d) Interpretation:
Kinds of amino acid released during urine excretion of animals having genetic deficiency in animals should be identified.
Concept Introduction:
Biosynthesis of vitamin B12 or cobalamin has aerobic and anaerobic pathways. Aerobic is where the chemical pathway needs oxygen and later cobalt is added. In anaerobic pathway, cobalt is added in the beginning and requires no oxygen. Biosynthesis of B12 as shown in the diagram produces 5-methyltetrahydrofolate as substrate. And methylmalonate is the compound formed in genetic deficient animal's urine. When the C enzyme loses its affinity towards a substrate injecting large amount of Vitamin B12 is reduced. Homocysteine is released during urine excretion.

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Chapter 18 Solutions
Biochemistry: Concepts and Connections
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- 2. Which one is the major organic product obtained from the following reaction? NaOH, H₂O heat A B C D Earrow_forwardCH3CH2CHO + propanal PhCH2CHO 2-phenylacetaldehyde mixture of four products NaOH 10. In the crossed aldol reaction of propanal and 2-phenylacetaldehyde shown above, a mixture of four products will be formed. Which ONE of the compounds below will NOT be formed in this crossed aldol reaction? OH Ph A H OH OH Ph H B OH OH H H H Ph Ph C Ph D Earrow_forwardAn organic chemist ordered the wrong item. She wanted to obtain 1-hydroxy-2-butanone, butinstead ordered 2-hydroxybutyraldehyde. As a good biochemist, show how the organic chemistcould use biological catalysis to make her desired compound.arrow_forward
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