Connect 1-Semester Online Access for Principles of General, Organic & Biochemistry
Connect 1-Semester Online Access for Principles of General, Organic & Biochemistry
2nd Edition
ISBN: 9780077633707
Author: Janice Smith
Publisher: Mcgraw-hill Higher Education (us)
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Chapter 18, Problem 18.71AP

(a)

Interpretation Introduction

Interpretation:

Role of FADH2 in electron transport chain has to be determined.

Concept Introduction:

Electron transport chain and oxidative phosphorylation is fourth stage for energy production. In this stage, O2 converts into water by help of NADH and FADH2 coenzymes. ATP is also produced in this stage. Reaction of formation of water is as follows:

  O2+4e+4H+2H2O

Four complexes are associated with electron transport chain that is present in inner mitochondrial membrane. These complexes are as follows:

Complex I: NADH-coenzyme Q reductase

Complex II: Succinate-coenzyme Q reductase

Complex III: Coenzyme Q-cytochrome reductase

Complex IV: Cytochrome c oxidase

(b)

Interpretation Introduction

Interpretation:

Role of ADP in electron transport chain has to be determined.

Concept Introduction:

Refer to part (a).

(c)

Interpretation Introduction

Interpretation:

Role of ATP synthase in electron transport chain has to be determined.

Concept Introduction:

Refer to part (a).

(d)

Interpretation Introduction

Interpretation:

Role of inner mitochondrial membrane in electron transport chain has to be determined.

Concept Introduction:

Refer to part (a).

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. Each gram of mammalian skeletal muscle consumes ATP at a rate of about 1x 10-3 mol/min during contraction. Concentrations of ATP and creatine phosphate in muscle are about 4 mM and 25 mM, respectively, and the density of muscle tissue can be taken to be about 1.2 g/cm'. (a) How long could contraction continue using ATP alone? (b) If all creatine phosphate were converted into ATP and utilized as well, how long could contraction continue? (c) What do these answers tell you?
To learn more about the role of the electron transport chain in generating energy during respiration in this organism, you use two drugs.  These drugs can each pick up electrons from specific intermediates in the pathway as shown above. You treat cells carrying out respiration with either a saturating dose of drug A or B, so that all the electrons which would normally continue along the pathway are captured by the drug in question. Complete the following table. In the presence of drug A, will the rate of ATP synthesis increase, decrease, or stay the same? Explain your reasoning.  In the presence of drug B, will the rate of ATP synthesis increase, decrease, or stay the same? Explain your reasoning.
The average adult consumes approximately 11,700 kJ per day. Assuming that the metabolic pathways leading to ATP synthesis operate at 50% thermodynamic efficiency, about 5850 kJ ends up in the form of synthesized ATP.       The average adult consumes approximately 11,700 kJ per day. Assuming that the metabolic pathways leading to ATP synthesis operate at 50% thermodynamic efficiency, about 5850 kJ ends up in the form of synthesized ATP. Imagine that creatine phosphate, rather than ATP, is the universal energy carrier molecule in the human body. Assume that the cellular concentrations of creatine phosphate, creatine, and phosphate are 21.7 mM, 2.17×10-3 mM, and 6.30 mM, respectively. Calculate the weight of creatine phosphate that would need to be consumed each day by a typical adult human if creatine phosphate could not be recycled. Estimate the free energy of hyrdolysis of creatine phosphate under cellular conditions to determine how many moles are required. Use the standard…
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