CONNECT FOR ANATOMY AND PHYSIOLOGY >IC
11th Edition
ISBN: 9781260018462
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 18, Problem 10RAC
Summary Introduction
Introduction:
T3 (triiodothyronine) and T4 (thyroxine) are the two hormones secreted from the thyroid gland. The secretion of these hormones is stimulated by a pituitary hormone called thyroid-stimulating hormone (TSH).
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 18 Solutions
CONNECT FOR ANATOMY AND PHYSIOLOGY >IC
Ch. 18.1 - Prob. 1AYPCh. 18.1 - Prob. 2AYPCh. 18.2 - Prob. 3AYPCh. 18.2 - Prob. 4AYPCh. 18.2 - How does the hypothalamus regulate the secretion...Ch. 18.2 - Prob. 6AYPCh. 18.2 - Prob. 7AYPCh. 18.2 - Prob. 8AYPCh. 18.2 - Prob. 9AYPCh. 18.2 - Prob. 10AYP
Ch. 18.2 - Prob. 11AYPCh. 18.2 - Prob. 12AYPCh. 18.2 - Prob. 13AYPCh. 18.2 - What effects do stress, blood amino acid levels,...Ch. 18.2 - Describe the effects of GH on its target tissues.Ch. 18.2 - Prob. 16AYPCh. 18.2 - Prob. 17AYPCh. 18.2 - Prob. 18AYPCh. 18.2 - For each of the following hormones secreted by the...Ch. 18.2 - Prob. 20AYPCh. 18.2 - What is a gonadotropin? Name two...Ch. 18.3 - Prob. 22AYPCh. 18.3 - Prob. 23AYPCh. 18.3 - How are the thyroid hormones transported in the...Ch. 18.3 - Prob. 25AYPCh. 18.3 - Starting in the hypothalamus, explain how chronic...Ch. 18.3 - Prob. 27AYPCh. 18.3 - Prob. 28AYPCh. 18.3 - Prob. 29AYPCh. 18.3 - What conditions cause hyperthyroidism? Describe...Ch. 18.3 - Prob. 31AYPCh. 18.4 - Prob. 32AYPCh. 18.4 - Prob. 33AYPCh. 18.4 - Prob. 34AYPCh. 18.4 - Prob. 35AYPCh. 18.4 - What can cause hypoparathyroidism?Describe the...Ch. 18.4 - Prob. 37AYPCh. 18.5 - Where are the adrenal glands located? Describe the...Ch. 18.5 - Name two hormones secreted by the adrenal medulla,...Ch. 18.5 - Prob. 40AYPCh. 18.5 - Prob. 41AYPCh. 18.5 - Name the target tissue ofaldosterone, and list...Ch. 18.5 - Prob. 43AYPCh. 18.5 - Prob. 44AYPCh. 18.5 - List the possible causes of hypersecretion of...Ch. 18.5 - Prob. 46AYPCh. 18.6 - Prob. 47AYPCh. 18.6 - Prob. 48AYPCh. 18.6 - How does insulin affect the satiety center of the...Ch. 18.6 - Prob. 50AYPCh. 18.6 - Prob. 51AYPCh. 18.7 - Prob. 52AYPCh. 18.7 - Prob. 53AYPCh. 18.7 - Prob. 54AYPCh. 18.8 - Prob. 55AYPCh. 18.8 - List the hormones secreted by the ovaries, and...Ch. 18.8 - What hormones from the anterior pituitary gland...Ch. 18.8 - Prob. 58AYPCh. 18.9 - Prob. 59AYPCh. 18.9 - Prob. 60AYPCh. 18.10 - What hormone is secreted by the thymus? What is...Ch. 18.10 - Prob. 62AYPCh. 18.10 - Prob. 63AYPCh. 18.10 - Prob. 64AYPCh. 18.10 - List examples of paracrine chemical messengers...Ch. 18.10 - Prob. 66AYPCh. 18.11 - Prob. 67AYPCh. 18.11 - Prob. 68AYPCh. 18 - The pituitary gland a. develops from the floor of...Ch. 18 - The hypothalamohypophysial portal system a....Ch. 18 - Prob. 3RACCh. 18 - Prob. 4RACCh. 18 - Prob. 5RACCh. 18 - Prob. 6RACCh. 18 - Prob. 7RACCh. 18 - Hypersecretion of growth hormone a.results in...Ch. 18 - Prob. 9RACCh. 18 - Prob. 10RACCh. 18 - Prob. 11RACCh. 18 - Prob. 12RACCh. 18 - Prob. 13RACCh. 18 - Parathyroid hormone secretion increases in...Ch. 18 - Prob. 15RACCh. 18 - Prob. 16RACCh. 18 - In the condition in which a benign tumor results...Ch. 18 - Which of these is nor a hormone secreted by the...Ch. 18 - Prob. 19RACCh. 18 - Prob. 20RACCh. 18 - Prob. 21RACCh. 18 - Within the pancreas, the pancreatic islets produce...Ch. 18 - Insulin increases a. the uptake of glucose by its...Ch. 18 - Prob. 24RACCh. 18 - Prob. 25RACCh. 18 - Prob. 26RACCh. 18 - Prob. 27RACCh. 18 - Prob. 28RACCh. 18 - Prob. 29RACCh. 18 - Prob. 30RACCh. 18 - Prob. 1CTCh. 18 - Prob. 2CTCh. 18 - A patient complains of headaches and visual...Ch. 18 - Prob. 4CTCh. 18 - Prob. 5CTCh. 18 - Prob. 6CTCh. 18 - Prob. 7CTCh. 18 - Predict some of the consequences of exposure to...Ch. 18 - Katie was getting nervous. At 16, she was the only...
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