Synthesis of ketoprofen from the given starting material is to be stated. Concept Introduction: The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2 -propionic acid. The molecular formula of this compound is C 16 H 14 O 3 . It is synthesized from a cyclic kenotic compound.

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Answer 1

Question

Chapter 18, Problem 103P

a)

Interpretation Introduction

Interpretation:

Synthesis of ketoprofen from the given starting material is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

b)

Interpretation Introduction

Interpretation:

The reasons corresponding to the different synthesis processes for both the ketoprofen and ibuprofen irrespective of common propionic acid sub unit is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

Ibuprofen is the non-steroidal and anti-inflammatory drug. It is used to treat pain, fever and inflammation.

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R₂ R₁ R₁ a R Rg Nu R₂ Rg R₁ R R₁₂ R3 R R Nu enolate forming R₁ R B-Alkylated carbonyl species or amines Cyclic B-Ketoester R₁₁ HOB R R₁B R R₁₂ B-Hydroxy carbonyl R diester R2 R3 R₁ RB OR R₂ 0 aB-Unsaturated carbonyl NaOR Aldol HOR reaction 1) LDA 2) R-X 3) H₂O/H₂O ketone, aldehyde 1) 2°-amine 2) acid chloride 3) H₂O'/H₂O 0 O R₁ R₁ R R₁ R₁₂ Alkylated a-carbon R₁ H.C R₁ H.C Alkylated methyl ketone acetoacetic ester B-Ketoester ester R₁ HO R₂ R B-Dicarbonyl HO Alkylated carboxylic acid malonic ester Write the reagents required to bring about each reaction next to the arrows shown. Next, record any regiochemistry or stereochemistry considerations relevant to the reaction. You should also record any key aspects of the mechanism, such as forma- tion of an important intermediate, as a helpful reminder. You may want to keep track of all reactions that make carbon-carbon bonds, because these help you build large molecules from smaller fragments. This especially applies to the reactions in…

Provide the reasonable steps to achieve the following synthesis.

Identify which compound is more acidic. Justify your choice.

Answer 2

Question

Chapter 18, Problem 103P

a)

Interpretation Introduction

Interpretation:

Synthesis of ketoprofen from the given starting material is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

b)

Interpretation Introduction

Interpretation:

The reasons corresponding to the different synthesis processes for both the ketoprofen and ibuprofen irrespective of common propionic acid sub unit is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

Ibuprofen is the non-steroidal and anti-inflammatory drug. It is used to treat pain, fever and inflammation.

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Answer 3

Question

Chapter 18, Problem 103P

a)

Interpretation Introduction

Interpretation:

Synthesis of ketoprofen from the given starting material is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

b)

Interpretation Introduction

Interpretation:

The reasons corresponding to the different synthesis processes for both the ketoprofen and ibuprofen irrespective of common propionic acid sub unit is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

Ibuprofen is the non-steroidal and anti-inflammatory drug. It is used to treat pain, fever and inflammation.

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Answer 4

Question

Chapter 18, Problem 103P

a)

Interpretation Introduction

Interpretation:

Synthesis of ketoprofen from the given starting material is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

b)

Interpretation Introduction

Interpretation:

The reasons corresponding to the different synthesis processes for both the ketoprofen and ibuprofen irrespective of common propionic acid sub unit is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

Ibuprofen is the non-steroidal and anti-inflammatory drug. It is used to treat pain, fever and inflammation.

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Answer 5

Chapter 18, Problem 103P

a)

Interpretation Introduction

Interpretation:

Synthesis of ketoprofen from the given starting material is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

b)

Interpretation Introduction

Interpretation:

The reasons corresponding to the different synthesis processes for both the ketoprofen and ibuprofen irrespective of common propionic acid sub unit is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

Ibuprofen is the non-steroidal and anti-inflammatory drug. It is used to treat pain, fever and inflammation.

Answer 6

Chapter 18, Problem 103P

a)

Interpretation Introduction

Interpretation:

Synthesis of ketoprofen from the given starting material is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

Answer 7

Chapter 18, Problem 103P

a)

Interpretation Introduction

Interpretation:

Synthesis of ketoprofen from the given starting material is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

Answer 8

b)

Interpretation Introduction

Interpretation:

The reasons corresponding to the different synthesis processes for both the ketoprofen and ibuprofen irrespective of common propionic acid sub unit is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

Ibuprofen is the non-steroidal and anti-inflammatory drug. It is used to treat pain, fever and inflammation.

Answer 9

b)

Interpretation Introduction

Interpretation:

The reasons corresponding to the different synthesis processes for both the ketoprofen and ibuprofen irrespective of common propionic acid sub unit is to be stated.

Concept Introduction:

The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is 2-propionic acid. The molecular formula of this compound is C₁₆H₁₄O₃. It is synthesized from a cyclic kenotic compound.

Ibuprofen is the non-steroidal and anti-inflammatory drug. It is used to treat pain, fever and inflammation.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 18.1 - Draw the structure for each of the following: a....Ch. 18.3 - Why does hydration inactivate FeBr3?Ch. 18.6 - Prob. 4P Ch. 18.7 - What is the major product of a Friedel-Crafts...Ch. 18.9 - Describe two ways to prepare each of the following...Ch. 18.10 - Prob. 7P Ch. 18.11 - Name the following:Ch. 18.11 - Draw a structure for each of the following: a....Ch. 18.11 - Draw the structure for each of the following: a....Ch. 18.11 - Correct the following incorrect names: a....

Solution Summary: The author explains that ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. It is synthesized from a cyclic kenotic compound.

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Chapter 18 Solutions