Biology (MindTap Course List)
11th Edition
ISBN: 9781337392938
Author: Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher: Cengage Learning
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Chapter 17.3, Problem 2C
Summary Introduction
To explain: The cause of development of cancers in the transplanted tissues during the stem cell transplant experiments.
Introduction: Stem cells are specialized cells that can be transformed into any type of cell in the body. There are various types depending on the type of cell. Pluripotent cells are formed by four genes that are used to reprogram differentiated cells.
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Chapter 17 Solutions
Biology (MindTap Course List)
Ch. 17.1 - Prob. 1LOCh. 17.1 - Describe the classic experiments of Steward,...Ch. 17.1 - Define stem cells, distinguish between embryonic...Ch. 17.1 - What lines of evidence support the principle of...Ch. 17.1 - Prob. 2CCh. 17.1 - What does the ability to produce iPSCs tell...Ch. 17.2 - Prob. 4LOCh. 17.2 - Prob. 5LOCh. 17.2 - Prob. 6LOCh. 17.2 - Prob. 7LO
Ch. 17.2 - Prob. 1CCh. 17.2 - Prob. 2CCh. 17.2 - Prob. 3CCh. 17.2 - Prob. 4CCh. 17.3 - Prob. 8LOCh. 17.3 - Prob. 1CCh. 17.3 - Prob. 2CCh. 17 - Prob. 1TYUCh. 17 - Prob. 2TYUCh. 17 - The anteriorposterior axis of a Drosophila embryo...Ch. 17 - Prob. 4TYUCh. 17 - Homeobox genes (a) are found in fruit flies but no...Ch. 17 - Prob. 6TYUCh. 17 - Prob. 7TYUCh. 17 - Which of the following statements about cancer is...Ch. 17 - Proto-oncogenes code for (a) morphogens (b)...Ch. 17 - Prob. 10TYUCh. 17 - Prob. 11TYUCh. 17 - Prob. 12TYUCh. 17 - CONNECT Why is an understanding of gene regulation...Ch. 17 - What is the reason that scientists study...Ch. 17 - Prob. 15TYUCh. 17 - Prob. 16TYUCh. 17 - EVOLUTION LINK What is the common ground between...Ch. 17 - INTERPRET DATA Flower parts are arranged in four...
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- The Human papillomavirus (HPV) has been linked to an increased risk of cervical cancer. The HPV E6 and E7 proteins govern the cell via altering cellular proteins. The E6 protein interacts with the tumor suppressor protein p53 and directs its ubiquitin-mediated destruction. Can you elaborate about the P63 gene: its function and if it can be altered/mutated by HPV? If it does, what is the relationship between P53 and P63? Thank you!arrow_forwardFollowing are the characteristics of organoids, except: Organoids are in vitro 3D clusters of cells deriving exclusively from primary tissue or stem cells Organoids are capable of self-renewal and self-organization. 2D monolayer cultures are much closer to the in vivo situation than the organoids Spatially restricted cell-fate decisions contribute to self-organization in organoids.arrow_forwardResearchers have identified some tumors that have no recurrent mutations or deletions in known oncogenes or tumor-suppressor genes and no detectable epigenetic alterations. However, these tumors often have large chromosomal deletions. What are some possible explanations that could account for the genetic causes behind these tumors?arrow_forward
- The p53 gene is a tumor-suppressor gene while Ras is a proto-oncogene. Mutation in either one can result in the transformation of a normal cell into a cancer cell. Explain the difference between the functions of the two proteins and how their mutation can lead to cancer development.arrow_forwardDescribe the general process of cell signalling pathways: what events take place for a signal to cause cellular changes? Provide examples and how perturbation of these events can result in “cancer pathways”. In addition, describe in detail a typical cancer pathway and its strategy to activate gene expression. What is the origin of many cancer pathways, i.e., during which stage of an organism’s live process(es) are they physiologically activated? Why is this important for cancer development?arrow_forwardDistinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do proto-oncogenes and tumor-suppressor genes undergo gain-of-function or loss-of-function mutations? Classify the following genes as proto-oncogenes or tumor-suppressor genes: p53, ras, BCL-2, JUN, MDM2, and p16.arrow_forward
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