Chapter 17.1, Problem 1CC

Summary Introduction

To determine: The disorder alkaptonuria is dominant or recessive. Garrod (1902) suggested that this condition is expressed when the faulty gene alleles are inherited from both the parents.

Concept introduction:

Alkaptonuria occurs due to the deficiency of the enzyme homogentisate 1, 2- dioxygenase. Thus, the body is unable to breakdown tyrosine and phenylalanine amino acids causing dark urine. In a research article by Garrod (1902) about alkaptonuria, he suggested that this disorder is caused when the abnormal allele is inherited from both the parents.