The effect of change in the structure of a subunit of G protein that prevents it from binding to GTP. Introduction: The eukaryotes have a special type of transmembrane receptors that are present in the plasma membrane. These are signaling molecules that interact with a particular type of proteins called G-proteins based on their binding ability with the nucleotide guanosine triphosphate and guanosine diphosphate, GTP and GDP respectively.

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Chapter 17, Problem 4CT

Summary Introduction

To analyze:

The effect of change in the structure of a subunit of G protein that prevents it from binding to GTP.

Introduction:

The eukaryotes have a special type of transmembrane receptors that are present in the plasma membrane. These are signaling molecules that interact with a particular type of proteins called G-proteins based on their binding ability with the nucleotide guanosine triphosphate and guanosine diphosphate, GTP and GDP respectively.

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Suppose that a G protein undergoes a mutation that allows the exchange of bound GTP for GDP to occur in the absence of G protein binding to a receptor. How might this mutation affect signaling involving a GPCR? Which subunit of the G protein is most likely affected by the mutation?

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