INTRO.TO GENERAL,ORGAN...-OWLV2 ACCESS
12th Edition
ISBN: 9781337915977
Author: Bettelheim
Publisher: CENGAGE L
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Chapter 17, Problem 13P
18-16 Propanedioic (malonic) acid forms an intramolecular hydrogen bond in which the H of one COOH group forms a hydrogen bond with an O of the other COOH group. Draw a structural formula to show this internal hydrogen bonding. (There are two possible answers.)
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Learning Goal:
As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7).
Part A - Difference in binding free eenergies
Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol.
The margin of error is 2%.
Part B - Compare difference in free energy to the thermal energy
Divide the…
Please correct answer and don't used hand raiting
Please correct answer and don't used hand raiting
Chapter 17 Solutions
INTRO.TO GENERAL,ORGAN...-OWLV2 ACCESS
Ch. 17.2 - Prob. 17.1QCCh. 17.5 - Prob. 17.2QCCh. 17.5 - Prob. 17.3QCCh. 17 - 18-4 Answer true or false. (a) The functional...Ch. 17 - Prob. 2PCh. 17 - 18-6 Name and draw structural formulas for the...Ch. 17 - 18-7 Write the IUPAC name for each carboxylic...Ch. 17 - 18-8 Write the IUPAC name for each carboxylic...Ch. 17 - Prob. 6PCh. 17 - Prob. 7P
Ch. 17 - Prob. 8PCh. 17 - Prob. 9PCh. 17 - Prob. 10PCh. 17 - 18-14 Answer true or false. (a) Carboxylic acids...Ch. 17 - 18-15 Draw a structural formula for the dimer...Ch. 17 - 18-16 Propanedioic (malonic) acid forms an...Ch. 17 - 18-17 Hexanoic (caproic) acid has a solubility in...Ch. 17 - 18-18 Propanoic acid and methyl acetate are...Ch. 17 - 18-19 The following compounds have approximately...Ch. 17 - Prob. 17PCh. 17 - Prob. 18PCh. 17 - Prob. 19PCh. 17 - 18-23 Characterize the structural features...Ch. 17 - Prob. 21PCh. 17 - Prob. 22PCh. 17 - 18-26 Answer true or false. (a) Carboxylic acids...Ch. 17 - Prob. 24PCh. 17 - 18-28 Arrange these compounds in order of...Ch. 17 - 18-29 Complete the equations for these acid—base...Ch. 17 - 18-30 Complete the equations for these acid-base...Ch. 17 - 18-31 Formic acid is one of the components...Ch. 17 - Prob. 29PCh. 17 - Prob. 30PCh. 17 - Prob. 31PCh. 17 - Prob. 32PCh. 17 - Prob. 33PCh. 17 - Prob. 34PCh. 17 - 18-38 Which is the stronger base: CH3CH2NH2 or...Ch. 17 - Prob. 36PCh. 17 - Prob. 37PCh. 17 - 18-41 Complete these examples of Fischer...Ch. 17 - Prob. 39PCh. 17 - Prob. 40PCh. 17 - Prob. 41PCh. 17 - Prob. 42PCh. 17 - 18-46 Procaine (its hydrochloride salt is marketed...Ch. 17 - 18-47 Methylparaben and propylparaben are used as...Ch. 17 - 18-48 4-Aminobenzoic acid is prepared from benzoic...Ch. 17 - Prob. 46PCh. 17 - Prob. 47PCh. 17 - Prob. 48PCh. 17 - Prob. 49PCh. 17 - Prob. 50PCh. 17 - Prob. 51PCh. 17 - Prob. 52P
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