SAPLINGPLUS FOR PRINCIPLES OF BIOCHEMIS
SAPLINGPLUS FOR PRINCIPLES OF BIOCHEMIS
7th Edition
ISBN: 9781319424572
Author: nelson
Publisher: MAC HIGHER
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Chapter 17, Problem 11P
Summary Introduction

To determine: The changes in metabolic pattern that would result from mutation in the muscle carnitine acyltransferase-1 in which the mutant protein has lost its affinity for malonyl-CoA but not its catalytic activity.

Introduction:

Shuttle system having intermediate fatty acyl-carnitine is needed to transport molecules of fatty acid into mitochondria. Before transportation of fatty acid molecules, fatty acids are first transformed into fatty-acyl coenzyme A in the cytoplasm which is done by acyl-CoA synthetase. After that fatty acyl groups are transported to carnitine present at the outer mitochondrial membrane by carnitine acyltransferase-1 enzyme.

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