Microbiology: An Introduction Plus Mastering Microbiology with Pearson eText -- Access Card Package (13th Edition) (What's New in Microbiology)
13th Edition
ISBN: 9780134688640
Author: Gerard J. Tortora, Berdell R. Funke, Christine L. Case, Derek Weber, Warner Bair
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Question
Chapter 17, Problem 10MCQ
Summary Introduction
Introduction:
Chediak-Higashi syndrome is an autosomal recessive syndrome, which affects the body parts. It damages the immune cells and makes the patient to go into an immunocompromised state, which helps in the invasion of bacteria and viruses into the body. The prolonged and persistent infections of bacteria and viruses lead to life threatening diseases or death.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Which of the following statements best explains why the immune system can continue to make antibodies after treatment with the anti-CD20 antibody rituximab?
a. New CD20-positive B cells are reconstituted so quickly that antibody concentration during and after treatment is unaffected.
b. Rituximab stimulates B-cell proliferation, so for a short while after its administration there is actually an increase in antibody concentration.
c. Rituximab is a mouse monoclonal antibody and therefore its Fc region is unable to bind to the surface
d. Plasma cells do not express CD20 on their cell surface, and antibody production by these cells continues unhampered.
e. Rituximab stimulates anti-antibody production, leading to its rapid clearance by the body.
Which of the following classes of oncogenes would likely be druggable with a small molecule (select all that apply)?
A.
Nuclear hormone receptor
B.
RAS
C.
Serine/Threoine Kinase
D.
Transcription Factor
E.
Receptor Tyrosine Kinase
Cancer cells have a complex interaction with the cells of the immune system that are present in the stroma. The immune cells have the potential to destroy the tumor if it is recognized as aberrant tissue. Which one of the following statements correctly describes an interaction between cancer cells and the immune cells of the stroma?
A. Tumors stimulate formation of new blood vessels—angiogenesis—promoting tumor survival.
B. The tumor establishes an immunosuppressive environment by blocking white-cell activation.
C. Tumors invoke an inflammatory reaction that blocks entry of immune cells into the stroma.
D. Immune cells block tumor growth by providing signals that inhibit cancer cell proliferation.
Chapter 17 Solutions
Microbiology: An Introduction Plus Mastering Microbiology with Pearson eText -- Access Card Package (13th Edition) (What's New in Microbiology)
Ch. 17 - Contrast the terms in the following pairs: a....Ch. 17 - What does MHC stand for? What is the function of...Ch. 17 - Why is dietary protein deficiency associated with...Ch. 17 - Prob. 4RCh. 17 - Prob. 5RCh. 17 - DRAW IT a. In the graph below, at time A the host...Ch. 17 - How would each of the following prevent infection?...Ch. 17 - Prob. 8RCh. 17 - Explain why a person who recovers from a disease...Ch. 17 - Prob. 10R
Ch. 17 - Prob. 1MCQCh. 17 - The type of protection provided by the injection...Ch. 17 - Prob. 3MCQCh. 17 - Prob. 4MCQCh. 17 - Prob. 5MCQCh. 17 - Prob. 6MCQCh. 17 - Prob. 7MCQCh. 17 - Prob. 8MCQCh. 17 - Prob. 9MCQCh. 17 - Prob. 10MCQCh. 17 - Prob. 1ACh. 17 - Why is dietary protein deficiency associated with...Ch. 17 - A positive tuberculin skin test shows cellular...Ch. 17 - On her vacation to Australia, Janet was bitten by...Ch. 17 - Prob. 1CAECh. 17 - Prob. 2CAECh. 17 - A patient with chronic diarrhea was found to lack...Ch. 17 - Newborns (under 1 year) who contract dengue have a...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Describe the mutational event that produces the MYC oncogene in Burkitt’s lymphoma. Why does the particular mechanism for generating oncogenic MYC result in a lymphoma rather than another type of cancer? Describe another mechanism for generating oncogenic MYC.arrow_forwardWhich of the following are mechanisms by which cancer drugs work (select all that apply)? A. Inhibit activity of oncogene B. Promote apoptosis C. Promote terminal differentiation of cells D. Inhibit drug transporters E. Promote DNA damage.arrow_forwardA graduate student wants to isolate cells from a patient and grow them perpetually in culture to study a non-cancer related pathology. Which two of the following genes could you introduce into these cells under control of a constitutive promoter to propogate these cells continuously in culture (select two)? A. Telomerase B. Retinoblastoma C. MDM2 D. p21 CIP E. SV40 Large T Antigenarrow_forward
- Researchers can make monoclonal antibodies by immunizing a mouse with a molecule (or with a microorganism). The resulting antibody-mediated response produces a set of antibodies that recognize different parts of the molecule. The mouse's B cells are then harvested from its spleen and fused with cancerous B cells from a myeloma cell line. The resulting hybrid myeloma ("hybridoma") cells are cloned: Individual cells are grown in tissue culture as separate cell lines. Each cell line produces and secretes antibodies that recognize one part of the immunizing molecule. These antibodies are called monoclonal antibodies, and they can be purified and used for research or other purposes. Monoclonal antibodies are effective for passive immunization, but only in the immediate term. Antibodies produced by one's own immune system can last up to about six months in the bloodstream, but monoclonals delivered in passive immunization often last for less than a week. Why the difference?arrow_forwardWhich of the following statements are correct about inflammation and cancer (select all that apply)? A. Inflammatory cells are often detected in tumor samples B. The inflammatory cytokine TNF has been shown to have direct transforming properties C. Cancer often arises at sites of chronic inflammation D. Use of NSAIDs has been associated with increased mortality from colorectal cancer E. Levels of macrophage infiltration in tumors have been negatively correlated with patient prognosisarrow_forwardRG, a 6-year-old child, has been diagnosed with Acute Lymphoblastic Leukemia (ALL). The standard treatment is 6-mercaptopurine (Purinethol), an inexpensive drug that inhibits proliferation and is effective against rapidly proliferating cells like cancer cells. The compound is an antimetabolite that interferes with DNA synthesis. However, about 10% of patients experience life-threatening toxicities. 6-mercaptopurine is metabolized and detoxified by the enzyme thiopurine-S-methyltransferase (TPMT). The most common SNPS correlated with low enzymatic activity are TPMT*3A, *3B, *3C and *2. They cause enhanced degradation of the enzyme. Genotyping reveals that RG has the following genotype: TPMT*3A/*2. Questions: A patient with TPMT*l/*1 should receive what kind of dose? Reduced dose Standard dose Increased dosearrow_forward
- Which ONE of the following molecular abnormalities is associated with the POOREST prognosis in acute myleoid leukaemia? A. t(8;21) translocaton (RUNX1_RUNX1fusion) B. DNMT3A mutation C. TP53 deletion D. NPM1 mutation.arrow_forwardRG, a 6-year-old child, has been diagnosed with Acute Lymphoblastic Leukemia (ALL). The standard treatment is 6-mercaptopurine (Purinethol), an inexpensive drug that inhibits proliferation and is effective against rapidly proliferating cells like cancer cells. The compound is an antimetabolite that interferes with DNA synthesis. However, about 10% of patients experience life-threatening toxicities. 6-mercaptopurine is metabolized and detoxified by the enzyme thiopurine-S-methyltransferase (TPMT). The most common SNPS correlated with low enzymatic activity are TPMT*3A, *3B, *3C and *2. They cause enhanced degradation of the enzyme. Genotyping reveals that RG has the following genotype: TPMT*3A/*2. Questions: 1. A patient with low TPMT enzyme activity would: Accumulate 6-mercaptopurine and experience toxic side effects Metabolize 6-mercaptopurine quickly and experience no anti-cancer benefits 2. The gene encoding TPMT has been sequenced in RG: TPMT*3A/*2. The patient would be classified…arrow_forwardDefine the following terms: a. cell transformation b. oncogene c. apoptosis d. early response gene e. delayed response genearrow_forward
- Based on Figure 2, which of the following best supports the claim that drug X inhibits oxygen consumption? a.In the absence of drug X, melanoma lines 1 and 4 consume similar amounts of oxygen. b.In the presence of drug X, melanoma line 2 consumes statistically more oxygen per cell than does melanoma line 3. c.Melanoma line 3 consumes statistically less oxygen per cell in the presence of drug X than it does in the presence of the solvent alone. d.Melanoma line 2 in the presence of drug X consumes statistically less oxygen than does melanoma line 4 in the absence of drug X.arrow_forwardFlow cytometry analysis was performed on the blood of an individual known to have been recently exposed to both rhinovirus (RV) and Mycobacterium tuberculosis (M.tb; an intracellular bacterial pathogen). Although an effective T cell response against RV was detected, a T cell response against M.tb was absent. Subsequently, genetic testing was performed, and the individual was found to possess two mutations. Below, indicate the MOST LIKELY mutations. A. T-bet; IL-12 B. CD28: IL-2Ra C. RORyT: IL-17 D. CD3: CD4arrow_forwardWe now have at least three SARS-CoV-2/COVID-19 vaccines approved by the FDA for use in the United States. These vaccines cause cells in the body to make the spike protein that is on the surface of the virus, and subsequently, stimulate an antibody response to this antigen. A. What do these antibodies do to prevent infection by SARS-CoV-2? How do they interact with the virus particles? B. Which kind of cells in the immune system are responsible for synthesizing these antibodies?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
QCE Biology: Introduction to Gene Expression; Author: Atomi;https://www.youtube.com/watch?v=a7hydUtCIJk;License: Standard YouTube License, CC-BY