Biology
4th Edition
ISBN: 9781259188121
Author: Peter Stiling, Robert Brooker, Linda Graham, Eric Widmaier
Publisher: McGraw-Hill Education
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Chapter 16, Problem 6TY
Summary Introduction
Introduction: Genetic disorder are caused due to abnormalities in the genome of a person and these disorders are inheritable from the parents to the offspring. Genetic disorders can be autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive, Y linked and mitochondrial disorders. For understanding the inheritance of human genetic diseases “Pedigree analysis” is considered the most effective tool and it follows simple Mendelian pattern.
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a. What is the mode of inheritance for this rare disease?
b. What is the genotype of the following (in cases where the genotype is uncertain, list all
possible genotypes.)
i.
1.1
ii.
1.2
ii.
II.1
iv.
I1.4
C. What is the likelihood that II.3 will have a child that is a carrier?
d.
What is the likelihood that II.2 has three affected children?
D. Sex-linked
In humans, hemophilia is a sex-linked trait. Females can be normal, carriers, or have the disease. Males
will either have the disease or not (but they won't ever be carriers).
1. Show the cross of a man who has hemophilia
with a normal woman. What is the probability
that their children will have the disease?
H
H
= female, normal
H h
X X = female, carrier
h
xxn
XHY
X" Y
2. A woman who is a carrier marries a hemophiliac
man. Show the cross. What is the probability
that their children will have hemophilia? What
sex will a child in the family with hemophilia be?
3. A woman who has hemophilia marries a normal man. How many of their children will have
hemophilia, and what is their sex?
= female, hemophiliac
= male, normal
= male, hemophiliac
A couple wish to have children, but the father has an X-linkedrecessive trait. Assuming that the mother does not carry thetrait, what percentage of their sons may inherit the trait?a. 0% d. 75%b. 25% e. 100%c. 50%
Chapter 16 Solutions
Biology
Ch. 16.1 - Prob. 1CCCh. 16.1 - Prob. 2CCCh. 16.1 - Prob. 3CCCh. 16.1 - Prob. 4CCCh. 16.1 - Prob. 5CCCh. 16.1 - Mendels Laws of Inheritance Concept Check: What...Ch. 16.2 - Prob. 1BCCh. 16.2 - Prob. 2BCCh. 16.2 - Prob. 1CCCh. 16.3 - Prob. 1CC
Ch. 16.3 - Prob. 2CCCh. 16.4 - Prob. 1CCCh. 16.4 - Prob. 1EQCh. 16.4 - Prob. 2EQCh. 16.4 - Prob. 3EQCh. 16.5 - Prob. 1CCCh. 16 - Prob. 1TYCh. 16 - During which phase of nuclear division does the...Ch. 16 - Prob. 3TYCh. 16 - Which of Mendels laws cannot be observed in a...Ch. 16 - During a __________blank, an individual with the...Ch. 16 - Prob. 6TYCh. 16 - Prob. 7TYCh. 16 - A hypothetical flowering plant species produces...Ch. 16 - Genes located on a sex chromosome are said to be...Ch. 16 - Prob. 10TYCh. 16 - Prob. 1CQCh. 16 - A cross is made between individuals having the...Ch. 16 - Core Concept: Systems We can view life as a...Ch. 16 - Discuss the principles of the chromosome theory of...Ch. 16 - When examining a human pedigree, what patterns do...
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- identify if it is True or False 1. ABO Blood Group show codominance. 2. Alleles are different forms of genes. 3. Sex-linked inheritance means that only the X-chromosomes are affected. 4. The carriers of hereditary materials are the genes. 5. Hemophilia is a sex-linked trait.arrow_forward3) Queen Victoria of England, who ruled from 1837-1901, is believed to have been the carrier of hemophilia. Hemophilia is an X-linked disease in which the blood is unable to form clots. Please make a Punnet Square using the scenario below and answer the following questions. Queen Victoria married a man who did not have the hemophilia trait or disease. What is the likelihood that they would have a child with hemophilia? What is the likelihood that they would have a son with hemophilia? What is the likelihood that they would have a daughter with hemophilia?arrow_forwardO. 2 Hemophilia A is an X-linked trait where blood clotting is affected due to a mutation in a clotting factor protein. Georgio has hemophilia and attends a support group where he meets Gbenga, who does not have the disease, but whose father has hemophilia. Her mother is not affected. A) If they marry, what percentage % of all their children will have hemophilia? % B) Georgio meets another woman, Maria, at the hemophilia support group. Maria also lacks the trait, but her mother has hemophilia while her father is unaffected. # 3 Would a Georgio-Maria mating provide a larger chance of having afflicted children compared to a Georgio-Gbenga mating? C) Show how you came up with your answer to B. Edit View Insert Format Tools Table 12pt ✓ 80 F3 V Paragraph ✓ $ 4 Yes or No 000 000 F4 DO LO % 5 BIUAV T² | F5 ^ MacBook Air 6 2 F6 V & 7 F7 * 8 DII F8 ( 9 DD F9 1 0 S Farrow_forward
- Which of the following can be identified by anabnormal karyotype?a. Sickle cell diseaseb. Cystic fibrosisc. Monosomy Xd. Tay-Sachs diseasee. Huntington’s choreaarrow_forwardHereditary hemochromatosis is an autosomal recessive genetic disorder that causes the body to absorb too much iron from the diet. This excess iron is stored in the body's tissues and organs, particularly the skin, heart, liver, pancreas, and joints. Because humans cannot increase the excretion of iron, excess iron can overload and eventually damage tissues and organs. A. Symptoms of hereditary hemochromatosis include fatigue, joint pain, arthritis, diabetes, heart disease, skin discoloration, delayed puberty in males, and premature menopause in women. All of these symptoms result a single mutation in a specific gene. Name and define this genetic phenomenon and explain how it relates to this specific genetic situation described above.arrow_forwardHemophilia A, a condition in which blood does not clot properly, is a recessive trait located on the X chromosome (Xh). A woman heterozygous for the trait marries a normal male. What is the probability that this couple will have hemophiliac daughters? What is the probability that this couple will have hemophiliac sons?arrow_forward
- Consider a woman whose brother has hemophilia A but whose parents are healthy. What is the chance that she has inherited the hemophilia allele? What is the chance that the woman will conceive a son with hemophilia?arrow_forwardA form of hemophilia is caused by a sex-linked (X-linked) recessive gene. A phenotypically normal woman whose father had hemophilia marries a man who suffers with hemophilia. What is the probability that their first daughter will have hemophilia?arrow_forwardHemophilia is a disease caused by a gene found on the X chromosome. Therefore, it is referred to as a sex-linked disease. The recessive allele causes the disease. A man with hemophilia (xhy) marries a woman who is homozygous dominant (XHXH. A. Illustrate using a Punnett square the probability that their children will have the disease. B. Will any of their children have the disease? C. Predict the probabilities of their children having the disease.arrow_forward
- Two forms of hemophilia are determined by genes on the X chromosome in humans. Assume that a phenotypically normal woman whose father had hemophilia is married to a normal man. What is their probability to have a son with hemophilia? (out of all children - not just the sons)arrow_forwardThe genetic disease hemophilia A is a sex-linked trait. Jane has an uncle on her father's side of the family who has hemophilia A, her father does not have hemophilia A. On Jane's mother's side of the family there has never been a case of hemophilia A. Should Jane be concerned about passing the gene for hemophilia A to her own children? Explain your answer.arrow_forwardAnswer the following: a. what environmental factors may increase incidence of chromosomal abnormalities? Name at least three. b. for a couple, what is the significance of knowing chromosomal aberrations?arrow_forward
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How to solve genetics probability problems; Author: Shomu's Biology;https://www.youtube.com/watch?v=R0yjfb1ooUs;License: Standard YouTube License, CC-BY
Beyond Mendelian Genetics: Complex Patterns of Inheritance; Author: Professor Dave Explains;https://www.youtube.com/watch?v=-EmvmBuK-B8;License: Standard YouTube License, CC-BY