ANATOMY AND PHYSIOLOGY
17th Edition
ISBN: 9781630180928
Author: OpenStax
Publisher: OPENSTAX C
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Chapter 16, Problem 42CTQ
Learning to ride a bike is a motor function dependent on the cerebellum. Why are the different regions of the cerebellum involved in this complex motor learning?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 16 Solutions
ANATOMY AND PHYSIOLOGY
Ch. 16 - Watch this video...Ch. 16 - Watch this video...Ch. 16 - Read this article...Ch. 16 - Watch the video...Ch. 16 - Watch this short video...Ch. 16 - Watch this video...Ch. 16 - Watch this video...Ch. 16 - Watch this short video...Ch. 16 - Which major section of the neurological exam is...Ch. 16 - What function would most likely be affected by a...
Ch. 16 - Which major section of the neurological exam...Ch. 16 - Memory, emotional, language, and sensorimotor...Ch. 16 - Where is language function localized in the...Ch. 16 - Which of the following could be elements of cyto...Ch. 16 - Which of the following could be a multimodal...Ch. 16 - Which is an example of episodic memory? how to...Ch. 16 - Which type of aphasia is more like hearing a...Ch. 16 - What region of the cerebral cortex is associated...Ch. 16 - Without olfactory sensation to complement...Ch. 16 - Which of the following cranial nerves is not part...Ch. 16 - Which nerve is responsible for controlling the...Ch. 16 - Which nerve is responsible for taste, as well as...Ch. 16 - Which of the following nerves controls movements...Ch. 16 - Which of the following is not part of the...Ch. 16 - Which subtest is directed at proprioceptive...Ch. 16 - What term describes the inability to lift the aim...Ch. 16 - Which type of reflex is the jaw-jerk reflex that...Ch. 16 - Which of the following is a feature of both...Ch. 16 - Which white matter structure carries information...Ch. 16 - Which region of the cerebellum receives...Ch. 16 - Which of the following tests cerebellar function...Ch. 16 - Which of the following is not a cause of...Ch. 16 - Which of the following functions cannot be...Ch. 16 - Why is a rapid assessment of neurological function...Ch. 16 - How is the diagnostic category of TIA different...Ch. 16 - A patients performance of the majority of the...Ch. 16 - A patient responds to the question What is your...Ch. 16 - As a person ages, their ability to focus on near...Ch. 16 - When a patient flexes their neck, the head tips to...Ch. 16 - The location of somatosensation is based on the...Ch. 16 - Why are upper motor neuron lesions characterized...Ch. 16 - Learning to ride a bike is a motor function...Ch. 16 - Alcohol intoxication can produce slurred speech....
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