Human Heredity: Principles and Issues
Human Heredity: Principles and Issues
11th Edition
ISBN: 9781305683952
Author: Michael Cummings
Publisher: Cengage Learning US
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Chapter 16, Problem 18QP

a.

Summary Introduction

To determine: The possible method to handle the scenario in which an individual should contact the proband beforehand to explain the results and the implications of the results.

Introduction: A couple has undergone a prenatal test in which the young woman (proband) is found to have the sickle cell trait (Ss), and her partner does not have the sickle cell anemia (SS). The woman’s family has a family history of sickle cell anemia. Their prenatal tests indicate that the fetus is affected with sickle cell anemia (ss) and the only way it is possible is when the woman’s partner is not the father of the fetus.

b.

Summary Introduction

To determine: Whether it is appropriate to keep the information from the partner as he believes he is the father of the baby and the other problems related to this case.

Introduction: A couple has undergone a prenatal test in which the young woman (proband) is found to have the sickle cell trait (Ss), and her partner does not have the sickle cell anemia (SS). The woman’s family has a family history of sickle cell anemia. Their prenatal tests indicate that the fetus is affected with sickle cell anemia (ss) and the only way it is possible is when the woman’s partner is not the father of the fetus.

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Imagine that you are a clinical geneticist. Your colleague is an oncologist who wants your help explaining the basics of genetics to their patient, who will be undergoing genetic testing in the coming weeks for possible acute myeloid leukemia (AML) induced by the radiation she had several years ago for breast cancer. Write a 1,050- to 1,225-word memo to your colleague. Include the following in your memo: An explanation of the molecular structure of DNA and RNA, highlighting both similarities and differences  A description of the processes of transcription and translation An explanation of the differences between leading and lagging strands and how the DNA is replicated in each strand Reponses to the following common questions patients might ask about this type of genetic testing and genetic disorder: Does AML run in families? What genes are tested for?
Respond to the following in a minimum of 175 words: What are some potential consequences that could result if the processes of replication, transcription, and translation don’t function correctly? Provide an example of how you might explain these consequences in terms that patients might understand.
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