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Jan is concerned about using ART. She wants to be the genetic mother and have Darryl be the genetic father of any children they have. What methods of ART would you recommend to this couple?
Jan, a 32-year-old woman, and her husband, Darryl, have been married for 7 years. They have attempted to have a baby on several occasions. Five years ago, they had a first-trimester miscarriage, followed by an ectopic pregnancy later the same year. Jan continued to see her OB/GYN physician for infertility problems but was very dissatisfied with the response. After four miscarriages, she went to see a fertility specialist, who diagnosed her with severe endometriosis and polycystic ovarian disease (detected by hormone studies). The infertility physician explained that these two conditions were hampering her ability to become pregnant and thus making her infertile. She referred Jan to a genetic counselor.
At the appointment, the counselor explained to Jan that one form of endometriosis (MIM 131200) can be a genetic disorder, and that polycystic ovarian disease can also be a genetic disorder (MIM 184700) and is one of the most common reproductive disorders among women. The counselor recommended that a detailed family history of both Jan and Darryl would help establish whether Jan’s problems have a genetic component and whether any of her potential daughters would be at risk for one or both of these disorders. In the meantime, Jan is taking hormones, and she and Darryl are considering alternative modes of reproduction.
Using the information in Figure 16.4, explain the reproductive options that are open to Jan and Darryl.
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Chapter 16 Solutions
Human Heredity: Principles and Issues
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- QUESTION 9 An animal cell has been wounded and has a small rupture in its plasma membrane. Which of the following is more likely to happen next? OA. The cell rapidly cleaves by cytokinesis. OB. The rate of receptor-mediati endocytosis is increased. OC. The rate of exocytosis is increased. OD. The rate of pinocytosis is increased.arrow_forwardFor the a subunit of a trimeric G protein, A. a G-protein-coupled receptor GPCR) acts as a guanine nucleotide exchange factor (GEF), whereas a regulator of G protein signaling (RGS) can act as a GTPase-activating protein (GAP). B. a GPCR acts as a GAP, whereas an RGS can act as a GEF. C. both a GPCR and an RGS can act as a GEF. O D. both a GPCR and an RGS can act as a GAP OE. None of the above.arrow_forwardA cell expresses a transmembrane protein that is cleaved at the plasma membrane to release an extracellular fragment. The fragment binds to receptor proteins on nearby cells and activates signaling pathways resulting in altered gene expression patterns in the cells. What form of intercellular signaling does this represent? OA. Contact-dependent signaling B. Paracrine signaling OC. Synaptic signaling D. Endocrine signaling E. Autocrine signalingarrow_forward
- Which of the following drive nuclearly encoded proteins import into the mitochondrial matrix? OA. ATP hydrolysis OB. Membrane Potential OC. K+ Ions OD. A and B OE. None of the abovearrow_forwardWhich of the following statements is true regarding Cholesterol import into the cell? OA. It is transported within LDL B. Receptor mediated endocytosis is involved OC. Release of cholesterol occurs in the Lysosome D. All of the above are true statements OE. None of the above are true statementsarrow_forwardIn which of the following schematic drawings of signaling pathways does the activation of the receptor lead to gene expression? Activating and inhibitory steps are indicated with (+) and (-), respectively. OA OB ㅇㅂㅇㅂㅇㅁ (+) Gene Expression Activated Signaling proteins Transcription receptor activator Bl D Gene Expression Gene Expression ㅁㅁㅇ Gene Expression Gene Expressionarrow_forward
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
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