Pearson eText Bauman Microbiology with Diseases by Body Systems -- Instant Access (Pearson+)
5th Edition
ISBN: 9780135891018
Author: ROBERT BAUMAN
Publisher: PEARSON+
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Chapter 15, Problem 1MTF
Modified True/False
1. _______ The surface cells of the epidermis of the skin are alive.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 15 Solutions
Pearson eText Bauman Microbiology with Diseases by Body Systems -- Instant Access (Pearson+)
Ch. 15 - Prob. 1TMWCh. 15 - Some strains of Staphylococcus aureus produce...Ch. 15 - Evaluating an Abnormal CBC Roger Brown, an African...Ch. 15 - The Stealth Invader Tim is often seen walking...Ch. 15 - Prob. 3TMWCh. 15 - Phagocytes of the epidermis are called _________....Ch. 15 - Mucus-secreting membranes are found in ________....Ch. 15 - The complement system involves _________. a. the...Ch. 15 - The alternative complement activation pathway...Ch. 15 - Which of the complement fragments is inflammatory?...
Ch. 15 - The type of interferon present late in an...Ch. 15 - Interferons ________. a. do not protect the cell...Ch. 15 - Prob. 8MCCh. 15 - Toll-like receptors (TLRs) act to ________. a....Ch. 15 - Prob. 10MCCh. 15 - Modified True/False 1. _______ The surface cells...Ch. 15 - Modified True/False 2. _______ The surface cells...Ch. 15 - Prob. 3MTFCh. 15 - Prob. 4MTFCh. 15 - Prob. 5MTFCh. 15 - Prob. 6MTFCh. 15 - Prob. 7MTFCh. 15 - Prob. 8MTFCh. 15 - Prob. 9MTFCh. 15 - Prob. 10MTFCh. 15 - Prob. 11MTFCh. 15 - Prob. 12MTFCh. 15 - Prob. 13MTFCh. 15 - Modified True/False 14. ___________________...Ch. 15 - Modified True/False 15. __________________ NETs...Ch. 15 - Prob. 1MCh. 15 - Write the letter of the description that applies...Ch. 15 - Label the steps of phagocytosis.Ch. 15 - Prob. 2VICh. 15 - In order for a pathogen to cause disease, what...Ch. 15 - How does a phagocyte know it is in contact with a...Ch. 15 - Give three characteristics of the epidermis that...Ch. 15 - What is the role of Toll-like receptors in innate...Ch. 15 - Describe the classical complement cascade pathway...Ch. 15 - Prob. 6SACh. 15 - John received a chemical burn on his arm and was...Ch. 15 - What might happen to someone whose body did not...Ch. 15 - Prob. 3CTCh. 15 - Prob. 4CTCh. 15 - There are two kinds of agranulocytes in the...Ch. 15 - A patient has a genetic disorder that prevents him...Ch. 15 - Prob. 7CTCh. 15 - Scientists can raise germ-free animals in axenic...Ch. 15 - Prob. 9CTCh. 15 - Scientists are interested in developing...Ch. 15 - A medical laboratory scientist argues that...Ch. 15 - A patient has a genetic disorder that makes it...Ch. 15 - Prob. 13CTCh. 15 - Prob. 14CTCh. 15 - Using the following terms, fill in the following...
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